CUG-binding protein 1 regulates HSC activation and liver fibrogenesis

CUG-binding protein 1 regulates HSC activation and liver fibrogenesis

Activation of hepatic stellate cells is a critical event in the development of fibrosis, which is driven by TGF-beta and inhibited by IFN-gamma. Here Wu et al. show that the RNA binding protein CUGBP1 is increased by TGF-beta signalling and promotes IFN-gamma mRNA degradation.

Saved in:
Bibliographic Details
Main Authors: Xingxin Wu, Xudong Wu, Yuxiang Ma, Fenli Shao, Yang Tan, Tao Tan, Liyun Gu, Yang Zhou, Beicheng Sun, Yang Sun, Xuefeng Wu, Qiang Xu
Format: article
Language:EN
Published: Nature Portfolio 2016
Subjects:
Science
Q
Online Access:https://doaj.org/article/ac7fe1e98e6e47c8a1df5add0cbe24dc
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items

Similar Items