Bulk tissue cell type deconvolution with multi-subject single-cell expression reference

Bulk tissue cell type deconvolution with multi-subject single-cell expression reference

Bulk tissue RNA-seq data reveals transcriptomic profiles but masks the contributions of different cell types. Here, the authors develop a new method for estimating cell type proportions from bulk tissue RNA-seq data guided by multi-subject single-cell expression reference.

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Autores principales: Xuran Wang, Jihwan Park, Katalin Susztak, Nancy R. Zhang, Mingyao Li
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/ac842de2714346f8a022547ffa6e51ad
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spelling oai:doaj.org-article:ac842de2714346f8a022547ffa6e51ad2021-12-02T17:32:10ZBulk tissue cell type deconvolution with multi-subject single-cell expression reference10.1038/s41467-018-08023-x2041-1723https://doaj.org/article/ac842de2714346f8a022547ffa6e51ad2019-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-08023-xhttps://doaj.org/toc/2041-1723Bulk tissue RNA-seq data reveals transcriptomic profiles but masks the contributions of different cell types. Here, the authors develop a new method for estimating cell type proportions from bulk tissue RNA-seq data guided by multi-subject single-cell expression reference.Xuran WangJihwan ParkKatalin SusztakNancy R. ZhangMingyao LiNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-9 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Xuran Wang
Jihwan Park
Katalin Susztak
Nancy R. Zhang
Mingyao Li
Bulk tissue cell type deconvolution with multi-subject single-cell expression reference
description Bulk tissue RNA-seq data reveals transcriptomic profiles but masks the contributions of different cell types. Here, the authors develop a new method for estimating cell type proportions from bulk tissue RNA-seq data guided by multi-subject single-cell expression reference.
format article
author Xuran Wang
Jihwan Park
Katalin Susztak
Nancy R. Zhang
Mingyao Li
author_facet Xuran Wang
Jihwan Park
Katalin Susztak
Nancy R. Zhang
Mingyao Li
author_sort Xuran Wang
title Bulk tissue cell type deconvolution with multi-subject single-cell expression reference
title_short Bulk tissue cell type deconvolution with multi-subject single-cell expression reference
title_full Bulk tissue cell type deconvolution with multi-subject single-cell expression reference
title_fullStr Bulk tissue cell type deconvolution with multi-subject single-cell expression reference
title_full_unstemmed Bulk tissue cell type deconvolution with multi-subject single-cell expression reference
title_sort bulk tissue cell type deconvolution with multi-subject single-cell expression reference
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/ac842de2714346f8a022547ffa6e51ad
work_keys_str_mv AT xuranwang bulktissuecelltypedeconvolutionwithmultisubjectsinglecellexpressionreference
AT jihwanpark bulktissuecelltypedeconvolutionwithmultisubjectsinglecellexpressionreference
AT katalinsusztak bulktissuecelltypedeconvolutionwithmultisubjectsinglecellexpressionreference
AT nancyrzhang bulktissuecelltypedeconvolutionwithmultisubjectsinglecellexpressionreference
AT mingyaoli bulktissuecelltypedeconvolutionwithmultisubjectsinglecellexpressionreference
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