Aβ receptors specifically recognize molecular features displayed by fibril ends and neurotoxic oligomers

PrPC, a receptor for Aβ oligomers, blocks polarized elongation of Aβ fibrils by binding to the rapidly growing end of each fibril. PrPC and other receptors may trap Aβ oligomers and protofibrils on the neuronal surface by binding to a common molecular determinant, initiating a neurotoxic signal.

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Detalles Bibliográficos
Autores principales: Ladan Amin, David A. Harris
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/ac93ade48c874d878eefe4d90fa6d6b1
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