Aβ receptors specifically recognize molecular features displayed by fibril ends and neurotoxic oligomers

PrPC, a receptor for Aβ oligomers, blocks polarized elongation of Aβ fibrils by binding to the rapidly growing end of each fibril. PrPC and other receptors may trap Aβ oligomers and protofibrils on the neuronal surface by binding to a common molecular determinant, initiating a neurotoxic signal.

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Detalles Bibliográficos
Autores principales:	Ladan Amin, David A. Harris
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ac93ade48c874d878eefe4d90fa6d6b1
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spelling	oai:doaj.org-article:ac93ade48c874d878eefe4d90fa6d6b12021-12-02T17:52:29ZAβ receptors specifically recognize molecular features displayed by fibril ends and neurotoxic oligomers10.1038/s41467-021-23507-z2041-1723https://doaj.org/article/ac93ade48c874d878eefe4d90fa6d6b12021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23507-zhttps://doaj.org/toc/2041-1723PrPC, a receptor for Aβ oligomers, blocks polarized elongation of Aβ fibrils by binding to the rapidly growing end of each fibril. PrPC and other receptors may trap Aβ oligomers and protofibrils on the neuronal surface by binding to a common molecular determinant, initiating a neurotoxic signal.Ladan AminDavid A. HarrisNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ladan Amin David A. Harris Aβ receptors specifically recognize molecular features displayed by fibril ends and neurotoxic oligomers
description	PrPC, a receptor for Aβ oligomers, blocks polarized elongation of Aβ fibrils by binding to the rapidly growing end of each fibril. PrPC and other receptors may trap Aβ oligomers and protofibrils on the neuronal surface by binding to a common molecular determinant, initiating a neurotoxic signal.
format	article
author	Ladan Amin David A. Harris
author_facet	Ladan Amin David A. Harris
author_sort	Ladan Amin
title	Aβ receptors specifically recognize molecular features displayed by fibril ends and neurotoxic oligomers
title_short	Aβ receptors specifically recognize molecular features displayed by fibril ends and neurotoxic oligomers
title_full	Aβ receptors specifically recognize molecular features displayed by fibril ends and neurotoxic oligomers
title_fullStr	Aβ receptors specifically recognize molecular features displayed by fibril ends and neurotoxic oligomers
title_full_unstemmed	Aβ receptors specifically recognize molecular features displayed by fibril ends and neurotoxic oligomers
title_sort	aβ receptors specifically recognize molecular features displayed by fibril ends and neurotoxic oligomers
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ac93ade48c874d878eefe4d90fa6d6b1
work_keys_str_mv	AT ladanamin abreceptorsspecificallyrecognizemolecularfeaturesdisplayedbyfibrilendsandneurotoxicoligomers AT davidaharris abreceptorsspecificallyrecognizemolecularfeaturesdisplayedbyfibrilendsandneurotoxicoligomers
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Aβ receptors specifically recognize molecular features displayed by fibril ends and neurotoxic oligomers

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