Genetic dissection of mammalian ERAD through comparative haploid and CRISPR forward genetic screens

Genetic dissection of mammalian ERAD through comparative haploid and CRISPR forward genetic screens

CRISPR/Cas9-mediated forward genetic screens and gene-trap mutagenesis screens in haploid cells are both powerful techniques to examine gene function. Here, the authors show the two approaches have high concordance and identify an uncharacterized gene, TXNDC11, which is involved in endoplasmic retic...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Richard T. Timms, Sam A. Menzies, Iva A. Tchasovnikarova, Lea C. Christensen, James C. Williamson, Robin Antrobus, Gordon Dougan, Lars Ellgaard, Paul J. Lehner
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/ace455e4f2ee40ba943423c1d8c92321
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares

Ejemplares similares