Regeneration of the exocrine pancreas is delayed in telomere-dysfunctional mice.

<h4>Introduction</h4>Telomere shortening is a cell-intrinsic mechanism that limits cell proliferation by induction of DNA damage responses resulting either in apoptosis or cellular senescence. Shortening of telomeres has been shown to occur during human aging and in chronic diseases that...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Guido von Figura, Martin Wagner, Kodandaramireddy Nalapareddy, Daniel Hartmann, Alexander Kleger, Luis Miguel Guachalla, Harshvardhan Rolyan, Guido Adler, Karl Lenhard Rudolph
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ad0f023bf29242328fdd0b2e65242941
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:ad0f023bf29242328fdd0b2e65242941
record_format	dspace
spelling	oai:doaj.org-article:ad0f023bf29242328fdd0b2e652429412021-11-18T06:58:27ZRegeneration of the exocrine pancreas is delayed in telomere-dysfunctional mice.1932-620310.1371/journal.pone.0017122https://doaj.org/article/ad0f023bf29242328fdd0b2e652429412011-02-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21364961/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Introduction</h4>Telomere shortening is a cell-intrinsic mechanism that limits cell proliferation by induction of DNA damage responses resulting either in apoptosis or cellular senescence. Shortening of telomeres has been shown to occur during human aging and in chronic diseases that accelerate cell turnover, such as chronic hepatitis. Telomere shortening can limit organ homeostasis and regeneration in response to injury. Whether the same holds true for pancreas regeneration in response to injury is not known.<h4>Methods</h4>In the present study, pancreatic regeneration after acute cerulein-induced pancreatitis was studied in late generation telomerase knockout mice with short telomeres compared to telomerase wild-type mice with long telomeres.<h4>Results</h4>Late generation telomerase knockout mice exhibited impaired exocrine pancreatic regeneration after acute pancreatitis as seen by persistence of metaplastic acinar cells and markedly reduced proliferation. The expression levels of p53 and p21 were not significantly increased in regenerating pancreas of late generation telomerase knockout mice compared to wild-type mice.<h4>Conclusion</h4>Our results indicate that pancreatic regeneration is limited in the context of telomere dysfunction without evidence for p53 checkpoint activation.Guido von FiguraMartin WagnerKodandaramireddy NalapareddyDaniel HartmannAlexander KlegerLuis Miguel GuachallaHarshvardhan RolyanGuido AdlerKarl Lenhard RudolphPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 2, p e17122 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Guido von Figura Martin Wagner Kodandaramireddy Nalapareddy Daniel Hartmann Alexander Kleger Luis Miguel Guachalla Harshvardhan Rolyan Guido Adler Karl Lenhard Rudolph Regeneration of the exocrine pancreas is delayed in telomere-dysfunctional mice.
description	<h4>Introduction</h4>Telomere shortening is a cell-intrinsic mechanism that limits cell proliferation by induction of DNA damage responses resulting either in apoptosis or cellular senescence. Shortening of telomeres has been shown to occur during human aging and in chronic diseases that accelerate cell turnover, such as chronic hepatitis. Telomere shortening can limit organ homeostasis and regeneration in response to injury. Whether the same holds true for pancreas regeneration in response to injury is not known.<h4>Methods</h4>In the present study, pancreatic regeneration after acute cerulein-induced pancreatitis was studied in late generation telomerase knockout mice with short telomeres compared to telomerase wild-type mice with long telomeres.<h4>Results</h4>Late generation telomerase knockout mice exhibited impaired exocrine pancreatic regeneration after acute pancreatitis as seen by persistence of metaplastic acinar cells and markedly reduced proliferation. The expression levels of p53 and p21 were not significantly increased in regenerating pancreas of late generation telomerase knockout mice compared to wild-type mice.<h4>Conclusion</h4>Our results indicate that pancreatic regeneration is limited in the context of telomere dysfunction without evidence for p53 checkpoint activation.
format	article
author	Guido von Figura Martin Wagner Kodandaramireddy Nalapareddy Daniel Hartmann Alexander Kleger Luis Miguel Guachalla Harshvardhan Rolyan Guido Adler Karl Lenhard Rudolph
author_facet	Guido von Figura Martin Wagner Kodandaramireddy Nalapareddy Daniel Hartmann Alexander Kleger Luis Miguel Guachalla Harshvardhan Rolyan Guido Adler Karl Lenhard Rudolph
author_sort	Guido von Figura
title	Regeneration of the exocrine pancreas is delayed in telomere-dysfunctional mice.
title_short	Regeneration of the exocrine pancreas is delayed in telomere-dysfunctional mice.
title_full	Regeneration of the exocrine pancreas is delayed in telomere-dysfunctional mice.
title_fullStr	Regeneration of the exocrine pancreas is delayed in telomere-dysfunctional mice.
title_full_unstemmed	Regeneration of the exocrine pancreas is delayed in telomere-dysfunctional mice.
title_sort	regeneration of the exocrine pancreas is delayed in telomere-dysfunctional mice.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/ad0f023bf29242328fdd0b2e65242941
work_keys_str_mv	AT guidovonfigura regenerationoftheexocrinepancreasisdelayedintelomeredysfunctionalmice AT martinwagner regenerationoftheexocrinepancreasisdelayedintelomeredysfunctionalmice AT kodandaramireddynalapareddy regenerationoftheexocrinepancreasisdelayedintelomeredysfunctionalmice AT danielhartmann regenerationoftheexocrinepancreasisdelayedintelomeredysfunctionalmice AT alexanderkleger regenerationoftheexocrinepancreasisdelayedintelomeredysfunctionalmice AT luismiguelguachalla regenerationoftheexocrinepancreasisdelayedintelomeredysfunctionalmice AT harshvardhanrolyan regenerationoftheexocrinepancreasisdelayedintelomeredysfunctionalmice AT guidoadler regenerationoftheexocrinepancreasisdelayedintelomeredysfunctionalmice AT karllenhardrudolph regenerationoftheexocrinepancreasisdelayedintelomeredysfunctionalmice
_version_	1718424126078582784

Regeneration of the exocrine pancreas is delayed in telomere-dysfunctional mice.

Ejemplares similares