Predictive Rules of Efflux Inhibition and Avoidance in Pseudomonas aeruginosa

Efflux pump avoidance and inhibition are desired properties for the optimization of antibacterial activities against Gram-negative bacteria. However, molecular and physicochemical interactions defining the interface between compounds and efflux pumps remain poorly understood. We identified propert...

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Autores principales:	Jitender Mehla, Giuliano Malloci, Rachael Mansbach, Cesar A. López, Ruslan Tsivkovski, Keith Haynes, Inga V. Leus, Sally B. Grindstaff, Robert H. Cascella, Napoleon D’Cunha, Liam Herndon, Nicolas W. Hengartner, Enrico Margiotta, Alessio Atzori, Attilio V. Vargiu, Pedro D. Manrique, John K. Walker, Olga Lomovskaya, Paolo Ruggerone, S. Gnanakaran, Valentin V. Rybenkov, Helen I. Zgurskaya
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2021
Materias:	Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/ad1e5b88030c459fa539ac7120f5edba
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spelling	oai:doaj.org-article:ad1e5b88030c459fa539ac7120f5edba2021-11-03T18:15:38ZPredictive Rules of Efflux Inhibition and Avoidance in Pseudomonas aeruginosa2161-21292150-751110.1128/mBio.02785-20https://doaj.org/article/ad1e5b88030c459fa539ac7120f5edba2021-02-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.02785-20https://doaj.org/toc/2161-2129https://doaj.org/toc/2150-7511 Efflux pump avoidance and inhibition are desired properties for the optimization of antibacterial activities against Gram-negative bacteria. However, molecular and physicochemical interactions defining the interface between compounds and efflux pumps remain poorly understood. We identified properties that correlate with efflux avoidance and inhibition, are predictive of similar features in structurally diverse compounds, and allow researchers to distinguish between efflux substrates, inhibitors, and avoiders in P. aeruginosaJitender MehlaGiuliano MallociRachael MansbachCesar A. LópezRuslan TsivkovskiKeith HaynesInga V. LeusSally B. GrindstaffRobert H. CascellaNapoleon D’CunhaLiam HerndonNicolas W. HengartnerEnrico MargiottaAlessio AtzoriAttilio V. VargiuPedro D. ManriqueJohn K. WalkerOlga LomovskayaPaolo RuggeroneS. GnanakaranValentin V. RybenkovHelen I. ZgurskayaAmerican Society for MicrobiologyarticleMicrobiologyQR1-502ENmBio, Vol 12, Iss 1 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Microbiology QR1-502
spellingShingle	Microbiology QR1-502 Jitender Mehla Giuliano Malloci Rachael Mansbach Cesar A. López Ruslan Tsivkovski Keith Haynes Inga V. Leus Sally B. Grindstaff Robert H. Cascella Napoleon D’Cunha Liam Herndon Nicolas W. Hengartner Enrico Margiotta Alessio Atzori Attilio V. Vargiu Pedro D. Manrique John K. Walker Olga Lomovskaya Paolo Ruggerone S. Gnanakaran Valentin V. Rybenkov Helen I. Zgurskaya Predictive Rules of Efflux Inhibition and Avoidance in Pseudomonas aeruginosa
description	Efflux pump avoidance and inhibition are desired properties for the optimization of antibacterial activities against Gram-negative bacteria. However, molecular and physicochemical interactions defining the interface between compounds and efflux pumps remain poorly understood. We identified properties that correlate with efflux avoidance and inhibition, are predictive of similar features in structurally diverse compounds, and allow researchers to distinguish between efflux substrates, inhibitors, and avoiders in P. aeruginosa
format	article
author	Jitender Mehla Giuliano Malloci Rachael Mansbach Cesar A. López Ruslan Tsivkovski Keith Haynes Inga V. Leus Sally B. Grindstaff Robert H. Cascella Napoleon D’Cunha Liam Herndon Nicolas W. Hengartner Enrico Margiotta Alessio Atzori Attilio V. Vargiu Pedro D. Manrique John K. Walker Olga Lomovskaya Paolo Ruggerone S. Gnanakaran Valentin V. Rybenkov Helen I. Zgurskaya
author_facet	Jitender Mehla Giuliano Malloci Rachael Mansbach Cesar A. López Ruslan Tsivkovski Keith Haynes Inga V. Leus Sally B. Grindstaff Robert H. Cascella Napoleon D’Cunha Liam Herndon Nicolas W. Hengartner Enrico Margiotta Alessio Atzori Attilio V. Vargiu Pedro D. Manrique John K. Walker Olga Lomovskaya Paolo Ruggerone S. Gnanakaran Valentin V. Rybenkov Helen I. Zgurskaya
author_sort	Jitender Mehla
title	Predictive Rules of Efflux Inhibition and Avoidance in Pseudomonas aeruginosa
title_short	Predictive Rules of Efflux Inhibition and Avoidance in Pseudomonas aeruginosa
title_full	Predictive Rules of Efflux Inhibition and Avoidance in Pseudomonas aeruginosa
title_fullStr	Predictive Rules of Efflux Inhibition and Avoidance in Pseudomonas aeruginosa
title_full_unstemmed	Predictive Rules of Efflux Inhibition and Avoidance in Pseudomonas aeruginosa
title_sort	predictive rules of efflux inhibition and avoidance in pseudomonas aeruginosa
publisher	American Society for Microbiology
publishDate	2021
url	https://doaj.org/article/ad1e5b88030c459fa539ac7120f5edba
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Predictive Rules of Efflux Inhibition and Avoidance in Pseudomonas aeruginosa

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