R-loop induced G-quadruplex in non-template promotes transcription by successive R-loop formation

R-loop induced G-quadruplex in non-template promotes transcription by successive R-loop formation

G-quadruplex (G4) forming sequences are highly enriched in the human genome and function as important regulators of diverse range of biological processes. Here the authors show that while G4 structures on template strand block transcription, folding on the non-template strand enhances transcription...

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Autores principales: Chun-Ying Lee, Christina McNerney, Kevin Ma, Walter Zhao, Ashley Wang, Sua Myong
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/ad1f87959bfc4d43bcb90955d7820fbc
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spelling oai:doaj.org-article:ad1f87959bfc4d43bcb90955d7820fbc2021-12-02T15:40:03ZR-loop induced G-quadruplex in non-template promotes transcription by successive R-loop formation10.1038/s41467-020-17176-72041-1723https://doaj.org/article/ad1f87959bfc4d43bcb90955d7820fbc2020-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17176-7https://doaj.org/toc/2041-1723G-quadruplex (G4) forming sequences are highly enriched in the human genome and function as important regulators of diverse range of biological processes. Here the authors show that while G4 structures on template strand block transcription, folding on the non-template strand enhances transcription by means of successive R-loop formation.Chun-Ying LeeChristina McNerneyKevin MaWalter ZhaoAshley WangSua MyongNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Chun-Ying Lee
Christina McNerney
Kevin Ma
Walter Zhao
Ashley Wang
Sua Myong
R-loop induced G-quadruplex in non-template promotes transcription by successive R-loop formation
description G-quadruplex (G4) forming sequences are highly enriched in the human genome and function as important regulators of diverse range of biological processes. Here the authors show that while G4 structures on template strand block transcription, folding on the non-template strand enhances transcription by means of successive R-loop formation.
format article
author Chun-Ying Lee
Christina McNerney
Kevin Ma
Walter Zhao
Ashley Wang
Sua Myong
author_facet Chun-Ying Lee
Christina McNerney
Kevin Ma
Walter Zhao
Ashley Wang
Sua Myong
author_sort Chun-Ying Lee
title R-loop induced G-quadruplex in non-template promotes transcription by successive R-loop formation
title_short R-loop induced G-quadruplex in non-template promotes transcription by successive R-loop formation
title_full R-loop induced G-quadruplex in non-template promotes transcription by successive R-loop formation
title_fullStr R-loop induced G-quadruplex in non-template promotes transcription by successive R-loop formation
title_full_unstemmed R-loop induced G-quadruplex in non-template promotes transcription by successive R-loop formation
title_sort r-loop induced g-quadruplex in non-template promotes transcription by successive r-loop formation
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/ad1f87959bfc4d43bcb90955d7820fbc
work_keys_str_mv AT chunyinglee rloopinducedgquadruplexinnontemplatepromotestranscriptionbysuccessiverloopformation
AT christinamcnerney rloopinducedgquadruplexinnontemplatepromotestranscriptionbysuccessiverloopformation
AT kevinma rloopinducedgquadruplexinnontemplatepromotestranscriptionbysuccessiverloopformation
AT walterzhao rloopinducedgquadruplexinnontemplatepromotestranscriptionbysuccessiverloopformation
AT ashleywang rloopinducedgquadruplexinnontemplatepromotestranscriptionbysuccessiverloopformation
AT suamyong rloopinducedgquadruplexinnontemplatepromotestranscriptionbysuccessiverloopformation
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