R-loop induced G-quadruplex in non-template promotes transcription by successive R-loop formation
G-quadruplex (G4) forming sequences are highly enriched in the human genome and function as important regulators of diverse range of biological processes. Here the authors show that while G4 structures on template strand block transcription, folding on the non-template strand enhances transcription...
Guardado en:
Autores principales: | Chun-Ying Lee, Christina McNerney, Kevin Ma, Walter Zhao, Ashley Wang, Sua Myong |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2020
|
Materias: | |
Acceso en línea: | https://doaj.org/article/ad1f87959bfc4d43bcb90955d7820fbc |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
Ejemplares similares
-
R-loop resolution promotes co-transcriptional chromatin silencing
por: Congyao Xu, et al.
Publicado: (2021) -
Structural dynamics of human telomeric G-quadruplex loops studied by molecular dynamics simulations.
por: Hong Zhu, et al.
Publicado: (2013) -
DHX9 helicase promotes R-loop formation in cells with impaired RNA splicing
por: Prasun Chakraborty, et al.
Publicado: (2018) -
Topoisomerase 1 prevents replication stress at R-loop-enriched transcription termination sites
por: Alexy Promonet, et al.
Publicado: (2020) -
A guanine-flipping and sequestration mechanism for G-quadruplex unwinding by RecQ helicases
por: Andrew F. Voter, et al.
Publicado: (2018)