Programming a topologically constrained DNA nanostructure into a sensor

DNA nanostructures with interlocked topologies will tend to display different behaviour to the linear counterparts. Here, the authors show a DNA catenane that is inactive for rolling circle amplification but is activated upon cleavage of one ring, and exploit this for the development of a biosensing...

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Autores principales: Meng Liu, Qiang Zhang, Zhongping Li, Jimmy Gu, John D. Brennan, Yingfu Li
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/ad34805213f748618cc14875c581add5
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