Programming a topologically constrained DNA nanostructure into a sensor

DNA nanostructures with interlocked topologies will tend to display different behaviour to the linear counterparts. Here, the authors show a DNA catenane that is inactive for rolling circle amplification but is activated upon cleavage of one ring, and exploit this for the development of a biosensing...

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Autores principales:	Meng Liu, Qiang Zhang, Zhongping Li, Jimmy Gu, John D. Brennan, Yingfu Li
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ad34805213f748618cc14875c581add5
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id	oai:doaj.org-article:ad34805213f748618cc14875c581add5
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spelling	oai:doaj.org-article:ad34805213f748618cc14875c581add52021-12-02T14:38:33ZProgramming a topologically constrained DNA nanostructure into a sensor10.1038/ncomms120742041-1723https://doaj.org/article/ad34805213f748618cc14875c581add52016-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms12074https://doaj.org/toc/2041-1723DNA nanostructures with interlocked topologies will tend to display different behaviour to the linear counterparts. Here, the authors show a DNA catenane that is inactive for rolling circle amplification but is activated upon cleavage of one ring, and exploit this for the development of a biosensing system.Meng LiuQiang ZhangZhongping LiJimmy GuJohn D. BrennanYingfu LiNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-7 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Meng Liu Qiang Zhang Zhongping Li Jimmy Gu John D. Brennan Yingfu Li Programming a topologically constrained DNA nanostructure into a sensor
description	DNA nanostructures with interlocked topologies will tend to display different behaviour to the linear counterparts. Here, the authors show a DNA catenane that is inactive for rolling circle amplification but is activated upon cleavage of one ring, and exploit this for the development of a biosensing system.
format	article
author	Meng Liu Qiang Zhang Zhongping Li Jimmy Gu John D. Brennan Yingfu Li
author_facet	Meng Liu Qiang Zhang Zhongping Li Jimmy Gu John D. Brennan Yingfu Li
author_sort	Meng Liu
title	Programming a topologically constrained DNA nanostructure into a sensor
title_short	Programming a topologically constrained DNA nanostructure into a sensor
title_full	Programming a topologically constrained DNA nanostructure into a sensor
title_fullStr	Programming a topologically constrained DNA nanostructure into a sensor
title_full_unstemmed	Programming a topologically constrained DNA nanostructure into a sensor
title_sort	programming a topologically constrained dna nanostructure into a sensor
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/ad34805213f748618cc14875c581add5
work_keys_str_mv	AT mengliu programmingatopologicallyconstraineddnananostructureintoasensor AT qiangzhang programmingatopologicallyconstraineddnananostructureintoasensor AT zhongpingli programmingatopologicallyconstraineddnananostructureintoasensor AT jimmygu programmingatopologicallyconstraineddnananostructureintoasensor AT johndbrennan programmingatopologicallyconstraineddnananostructureintoasensor AT yingfuli programmingatopologicallyconstraineddnananostructureintoasensor
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Programming a topologically constrained DNA nanostructure into a sensor

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