Paracrine effect of regulatory T cells promotes cardiomyocyte proliferation during pregnancy and after myocardial infarction

Regulatory T cells (Tregs) expand during pregnancy to promote tolerance towards the fetus. Here the authors show that Tregs induce proliferation of fetal and maternal cardiomyocytes during pregnancy and enhance myocardial repair via proliferation-promoting paracrine actions.

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Autores principales:	Serena Zacchigna, Valentina Martinelli, Silvia Moimas, Andrea Colliva, Marco Anzini, Andrea Nordio, Alessia Costa, Michael Rehman, Simone Vodret, Cristina Pierro, Giulia Colussi, Lorena Zentilin, Maria Ines Gutierrez, Ellen Dirkx, Carlin Long, Gianfranco Sinagra, David Klatzmann, Mauro Giacca
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ad5cacc548e5430492ee946cd053a017
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spelling	oai:doaj.org-article:ad5cacc548e5430492ee946cd053a0172021-12-02T17:32:44ZParacrine effect of regulatory T cells promotes cardiomyocyte proliferation during pregnancy and after myocardial infarction10.1038/s41467-018-04908-z2041-1723https://doaj.org/article/ad5cacc548e5430492ee946cd053a0172018-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04908-zhttps://doaj.org/toc/2041-1723Regulatory T cells (Tregs) expand during pregnancy to promote tolerance towards the fetus. Here the authors show that Tregs induce proliferation of fetal and maternal cardiomyocytes during pregnancy and enhance myocardial repair via proliferation-promoting paracrine actions.Serena ZacchignaValentina MartinelliSilvia MoimasAndrea CollivaMarco AnziniAndrea NordioAlessia CostaMichael RehmanSimone VodretCristina PierroGiulia ColussiLorena ZentilinMaria Ines GutierrezEllen DirkxCarlin LongGianfranco SinagraDavid KlatzmannMauro GiaccaNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Serena Zacchigna Valentina Martinelli Silvia Moimas Andrea Colliva Marco Anzini Andrea Nordio Alessia Costa Michael Rehman Simone Vodret Cristina Pierro Giulia Colussi Lorena Zentilin Maria Ines Gutierrez Ellen Dirkx Carlin Long Gianfranco Sinagra David Klatzmann Mauro Giacca Paracrine effect of regulatory T cells promotes cardiomyocyte proliferation during pregnancy and after myocardial infarction
description	Regulatory T cells (Tregs) expand during pregnancy to promote tolerance towards the fetus. Here the authors show that Tregs induce proliferation of fetal and maternal cardiomyocytes during pregnancy and enhance myocardial repair via proliferation-promoting paracrine actions.
format	article
author	Serena Zacchigna Valentina Martinelli Silvia Moimas Andrea Colliva Marco Anzini Andrea Nordio Alessia Costa Michael Rehman Simone Vodret Cristina Pierro Giulia Colussi Lorena Zentilin Maria Ines Gutierrez Ellen Dirkx Carlin Long Gianfranco Sinagra David Klatzmann Mauro Giacca
author_facet	Serena Zacchigna Valentina Martinelli Silvia Moimas Andrea Colliva Marco Anzini Andrea Nordio Alessia Costa Michael Rehman Simone Vodret Cristina Pierro Giulia Colussi Lorena Zentilin Maria Ines Gutierrez Ellen Dirkx Carlin Long Gianfranco Sinagra David Klatzmann Mauro Giacca
author_sort	Serena Zacchigna
title	Paracrine effect of regulatory T cells promotes cardiomyocyte proliferation during pregnancy and after myocardial infarction
title_short	Paracrine effect of regulatory T cells promotes cardiomyocyte proliferation during pregnancy and after myocardial infarction
title_full	Paracrine effect of regulatory T cells promotes cardiomyocyte proliferation during pregnancy and after myocardial infarction
title_fullStr	Paracrine effect of regulatory T cells promotes cardiomyocyte proliferation during pregnancy and after myocardial infarction
title_full_unstemmed	Paracrine effect of regulatory T cells promotes cardiomyocyte proliferation during pregnancy and after myocardial infarction
title_sort	paracrine effect of regulatory t cells promotes cardiomyocyte proliferation during pregnancy and after myocardial infarction
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/ad5cacc548e5430492ee946cd053a017
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Paracrine effect of regulatory T cells promotes cardiomyocyte proliferation during pregnancy and after myocardial infarction

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