Systems biology approach reveals a link between mTORC1 and G2/M DNA damage checkpoint recovery

DNA damage induces checkpoints to ensure that damage is not transferred to the next generation, but the molecular pathways responsible for checkpoint recovery are not clear. Here the authors show that the nutrient sensor mTORC1 is a determinant for G2/M checkpoint recovery through regulation of cycl...

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Autores principales:	Hui-Ju Hsieh, Wei Zhang, Shu-Hong Lin, Wen-Hao Yang, Jun-Zhong Wang, Jianfeng Shen, Yiran Zhang, Yiling Lu, Hua Wang, Jane Yu, Gordon B. Mills, Guang Peng
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ad5ed566daba45c88b9e968e15d44b34
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spelling	oai:doaj.org-article:ad5ed566daba45c88b9e968e15d44b342021-12-02T16:49:21ZSystems biology approach reveals a link between mTORC1 and G2/M DNA damage checkpoint recovery10.1038/s41467-018-05639-x2041-1723https://doaj.org/article/ad5ed566daba45c88b9e968e15d44b342018-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05639-xhttps://doaj.org/toc/2041-1723DNA damage induces checkpoints to ensure that damage is not transferred to the next generation, but the molecular pathways responsible for checkpoint recovery are not clear. Here the authors show that the nutrient sensor mTORC1 is a determinant for G2/M checkpoint recovery through regulation of cyclin B1 and PLK1 expression.Hui-Ju HsiehWei ZhangShu-Hong LinWen-Hao YangJun-Zhong WangJianfeng ShenYiran ZhangYiling LuHua WangJane YuGordon B. MillsGuang PengNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hui-Ju Hsieh Wei Zhang Shu-Hong Lin Wen-Hao Yang Jun-Zhong Wang Jianfeng Shen Yiran Zhang Yiling Lu Hua Wang Jane Yu Gordon B. Mills Guang Peng Systems biology approach reveals a link between mTORC1 and G2/M DNA damage checkpoint recovery
description	DNA damage induces checkpoints to ensure that damage is not transferred to the next generation, but the molecular pathways responsible for checkpoint recovery are not clear. Here the authors show that the nutrient sensor mTORC1 is a determinant for G2/M checkpoint recovery through regulation of cyclin B1 and PLK1 expression.
format	article
author	Hui-Ju Hsieh Wei Zhang Shu-Hong Lin Wen-Hao Yang Jun-Zhong Wang Jianfeng Shen Yiran Zhang Yiling Lu Hua Wang Jane Yu Gordon B. Mills Guang Peng
author_facet	Hui-Ju Hsieh Wei Zhang Shu-Hong Lin Wen-Hao Yang Jun-Zhong Wang Jianfeng Shen Yiran Zhang Yiling Lu Hua Wang Jane Yu Gordon B. Mills Guang Peng
author_sort	Hui-Ju Hsieh
title	Systems biology approach reveals a link between mTORC1 and G2/M DNA damage checkpoint recovery
title_short	Systems biology approach reveals a link between mTORC1 and G2/M DNA damage checkpoint recovery
title_full	Systems biology approach reveals a link between mTORC1 and G2/M DNA damage checkpoint recovery
title_fullStr	Systems biology approach reveals a link between mTORC1 and G2/M DNA damage checkpoint recovery
title_full_unstemmed	Systems biology approach reveals a link between mTORC1 and G2/M DNA damage checkpoint recovery
title_sort	systems biology approach reveals a link between mtorc1 and g2/m dna damage checkpoint recovery
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/ad5ed566daba45c88b9e968e15d44b34
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Systems biology approach reveals a link between mTORC1 and G2/M DNA damage checkpoint recovery

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