Unstable Mechanisms of Resistance to Inhibitors of <named-content content-type="genus-species">Escherichia coli</named-content> Lipoprotein Signal Peptidase

Unstable Mechanisms of Resistance to Inhibitors of <named-content content-type="genus-species">Escherichia coli</named-content> Lipoprotein Signal Peptidase

ABSTRACT Clinical development of antibiotics with novel mechanisms of action to kill pathogenic bacteria is challenging, in part, due to the inevitable emergence of resistance. A phenomenon of potential clinical importance that is broadly overlooked in preclinical development is heteroresistance, an...

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Autores principales: Homer Pantua, Elizabeth Skippington, Marie-Gabrielle Braun, Cameron L. Noland, Jingyu Diao, Yutian Peng, Susan L. Gloor, Donghong Yan, Jing Kang, Anand Kumar Katakam, Janina Reeder, Georgette M. Castanedo, Keira Garland, Laszlo Komuves, Meredith Sagolla, Cary D. Austin, Jeremy Murray, Yiming Xu, Zora Modrusan, Min Xu, Emily J. Hanan, Sharookh B. Kapadia
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2020
Materias:
heteroresistance
lipoprotein
Lpp
LspA
globomycin
Microbiology
QR1-502
Acceso en línea:https://doaj.org/article/ad7dc0127d394ca78d233d455e860331
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