The Cellular NMD Pathway Restricts Zika Virus Infection and Is Targeted by the Viral Capsid Protein

ABSTRACT Zika virus (ZIKV) infection of neural progenitor cells (NPCs) in utero is associated with neurological disorders, such as microcephaly, but a detailed molecular understanding of ZIKV-induced pathogenesis is lacking. Here we show that in vitro ZIKV infection of human cells, including NPCs, c...

Full description

Saved in:
Bibliographic Details
Main Authors: Krystal A. Fontaine, Kristoffer E. Leon, Mir M. Khalid, Sakshi Tomar, David Jimenez-Morales, Mariah Dunlap, Julia A. Kaye, Priya S. Shah, Steve Finkbeiner, Nevan J. Krogan, Melanie Ott
Format: article
Language:EN
Published: American Society for Microbiology 2018
Subjects:
Online Access:https://doaj.org/article/ad85e194b2514640959c6776d3129874
Tags: Add Tag
No Tags, Be the first to tag this record!