p85β regulates autophagic degradation of AXL to activate oncogenic signaling

p85β regulates autophagic degradation of AXL to activate oncogenic signaling

p85β (PIK3R2), a regulatory subunit of PI3K, has oncogenic properties. Here the authors show that p85β promotes AXL protein stability, which in turn activates p110 to induce PDK1/SGK3 signaling, and therapeutically, p85β-expressing ovarian cancer cells are sensitive to AXL inhibition.

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Detalles Bibliográficos
Autores principales: Ling Rao, Victor C. Y. Mak, Yuan Zhou, Dong Zhang, Xinran Li, Chloe C. Y. Fung, Rakesh Sharma, Chao Gu, Yiling Lu, George L. Tipoe, Annie N. Y. Cheung, Gordon B. Mills, Lydia W. T. Cheung
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Science
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Acceso en línea:https://doaj.org/article/adc6777a01c94b29a362d31af3cc89e0
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Descripción
Sumario:p85β (PIK3R2), a regulatory subunit of PI3K, has oncogenic properties. Here the authors show that p85β promotes AXL protein stability, which in turn activates p110 to induce PDK1/SGK3 signaling, and therapeutically, p85β-expressing ovarian cancer cells are sensitive to AXL inhibition.

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