p85β regulates autophagic degradation of AXL to activate oncogenic signaling

p85β (PIK3R2), a regulatory subunit of PI3K, has oncogenic properties. Here the authors show that p85β promotes AXL protein stability, which in turn activates p110 to induce PDK1/SGK3 signaling, and therapeutically, p85β-expressing ovarian cancer cells are sensitive to AXL inhibition.

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Autores principales:	Ling Rao, Victor C. Y. Mak, Yuan Zhou, Dong Zhang, Xinran Li, Chloe C. Y. Fung, Rakesh Sharma, Chao Gu, Yiling Lu, George L. Tipoe, Annie N. Y. Cheung, Gordon B. Mills, Lydia W. T. Cheung
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/adc6777a01c94b29a362d31af3cc89e0
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spelling	oai:doaj.org-article:adc6777a01c94b29a362d31af3cc89e02021-12-02T15:34:34Zp85β regulates autophagic degradation of AXL to activate oncogenic signaling10.1038/s41467-020-16061-72041-1723https://doaj.org/article/adc6777a01c94b29a362d31af3cc89e02020-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16061-7https://doaj.org/toc/2041-1723p85β (PIK3R2), a regulatory subunit of PI3K, has oncogenic properties. Here the authors show that p85β promotes AXL protein stability, which in turn activates p110 to induce PDK1/SGK3 signaling, and therapeutically, p85β-expressing ovarian cancer cells are sensitive to AXL inhibition.Ling RaoVictor C. Y. MakYuan ZhouDong ZhangXinran LiChloe C. Y. FungRakesh SharmaChao GuYiling LuGeorge L. TipoeAnnie N. Y. CheungGordon B. MillsLydia W. T. CheungNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ling Rao Victor C. Y. Mak Yuan Zhou Dong Zhang Xinran Li Chloe C. Y. Fung Rakesh Sharma Chao Gu Yiling Lu George L. Tipoe Annie N. Y. Cheung Gordon B. Mills Lydia W. T. Cheung p85β regulates autophagic degradation of AXL to activate oncogenic signaling
description	p85β (PIK3R2), a regulatory subunit of PI3K, has oncogenic properties. Here the authors show that p85β promotes AXL protein stability, which in turn activates p110 to induce PDK1/SGK3 signaling, and therapeutically, p85β-expressing ovarian cancer cells are sensitive to AXL inhibition.
format	article
author	Ling Rao Victor C. Y. Mak Yuan Zhou Dong Zhang Xinran Li Chloe C. Y. Fung Rakesh Sharma Chao Gu Yiling Lu George L. Tipoe Annie N. Y. Cheung Gordon B. Mills Lydia W. T. Cheung
author_facet	Ling Rao Victor C. Y. Mak Yuan Zhou Dong Zhang Xinran Li Chloe C. Y. Fung Rakesh Sharma Chao Gu Yiling Lu George L. Tipoe Annie N. Y. Cheung Gordon B. Mills Lydia W. T. Cheung
author_sort	Ling Rao
title	p85β regulates autophagic degradation of AXL to activate oncogenic signaling
title_short	p85β regulates autophagic degradation of AXL to activate oncogenic signaling
title_full	p85β regulates autophagic degradation of AXL to activate oncogenic signaling
title_fullStr	p85β regulates autophagic degradation of AXL to activate oncogenic signaling
title_full_unstemmed	p85β regulates autophagic degradation of AXL to activate oncogenic signaling
title_sort	p85β regulates autophagic degradation of axl to activate oncogenic signaling
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/adc6777a01c94b29a362d31af3cc89e0
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p85β regulates autophagic degradation of AXL to activate oncogenic signaling

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