Intellectual disability-associated factor Zbtb11 cooperates with NRF-2/GABP to control mitochondrial function

ZBTB11 mutations have been identified in patients with intellectual disability and morphological brain and neuromuscular defects, although the etiology was unknown. Here, the authors demonstrate that ZBTB11 regulates mitochondrial function by facilitating NRF-2-mediated activation of complex I and m...

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Autores principales:	Brooke C. Wilson, Lena Boehme, Ambra Annibali, Alan Hodgkinson, Thomas S. Carroll, Rebecca J. Oakey, Vlad C. Seitan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/adf8d876f768497c8f62fbbc52bfdbe3
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spelling	oai:doaj.org-article:adf8d876f768497c8f62fbbc52bfdbe32021-12-02T15:37:12ZIntellectual disability-associated factor Zbtb11 cooperates with NRF-2/GABP to control mitochondrial function10.1038/s41467-020-19205-x2041-1723https://doaj.org/article/adf8d876f768497c8f62fbbc52bfdbe32020-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19205-xhttps://doaj.org/toc/2041-1723ZBTB11 mutations have been identified in patients with intellectual disability and morphological brain and neuromuscular defects, although the etiology was unknown. Here, the authors demonstrate that ZBTB11 regulates mitochondrial function by facilitating NRF-2-mediated activation of complex I and mitoribosome genes.Brooke C. WilsonLena BoehmeAmbra AnnibaliAlan HodgkinsonThomas S. CarrollRebecca J. OakeyVlad C. SeitanNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-20 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Brooke C. Wilson Lena Boehme Ambra Annibali Alan Hodgkinson Thomas S. Carroll Rebecca J. Oakey Vlad C. Seitan Intellectual disability-associated factor Zbtb11 cooperates with NRF-2/GABP to control mitochondrial function
description	ZBTB11 mutations have been identified in patients with intellectual disability and morphological brain and neuromuscular defects, although the etiology was unknown. Here, the authors demonstrate that ZBTB11 regulates mitochondrial function by facilitating NRF-2-mediated activation of complex I and mitoribosome genes.
format	article
author	Brooke C. Wilson Lena Boehme Ambra Annibali Alan Hodgkinson Thomas S. Carroll Rebecca J. Oakey Vlad C. Seitan
author_facet	Brooke C. Wilson Lena Boehme Ambra Annibali Alan Hodgkinson Thomas S. Carroll Rebecca J. Oakey Vlad C. Seitan
author_sort	Brooke C. Wilson
title	Intellectual disability-associated factor Zbtb11 cooperates with NRF-2/GABP to control mitochondrial function
title_short	Intellectual disability-associated factor Zbtb11 cooperates with NRF-2/GABP to control mitochondrial function
title_full	Intellectual disability-associated factor Zbtb11 cooperates with NRF-2/GABP to control mitochondrial function
title_fullStr	Intellectual disability-associated factor Zbtb11 cooperates with NRF-2/GABP to control mitochondrial function
title_full_unstemmed	Intellectual disability-associated factor Zbtb11 cooperates with NRF-2/GABP to control mitochondrial function
title_sort	intellectual disability-associated factor zbtb11 cooperates with nrf-2/gabp to control mitochondrial function
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/adf8d876f768497c8f62fbbc52bfdbe3
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Intellectual disability-associated factor Zbtb11 cooperates with NRF-2/GABP to control mitochondrial function

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