The tumour suppressor APC promotes HIV-1 assembly via interaction with Gag precursor protein

The tumour suppressor APC is a multifunctional protein implicated in intracellular localization of mRNAs and WNT signalling. Here, Miyakawaet al. show that, via interaction with the HIV Gag precursor protein, APC promotes membrane targeting of viral components and cell-to-cell spread of HIV.

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Autores principales:	Kei Miyakawa, Mayuko Nishi, Satoko Matsunaga, Akiko Okayama, Masaki Anraku, Ayumi Kudoh, Hisashi Hirano, Hirokazu Kimura, Yuko Morikawa, Naoki Yamamoto, Akira Ono, Akihide Ryo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ae209f474cd54f76a8408cf01cef6786
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spelling	oai:doaj.org-article:ae209f474cd54f76a8408cf01cef67862021-12-02T14:41:08ZThe tumour suppressor APC promotes HIV-1 assembly via interaction with Gag precursor protein10.1038/ncomms142592041-1723https://doaj.org/article/ae209f474cd54f76a8408cf01cef67862017-01-01T00:00:00Zhttps://doi.org/10.1038/ncomms14259https://doaj.org/toc/2041-1723The tumour suppressor APC is a multifunctional protein implicated in intracellular localization of mRNAs and WNT signalling. Here, Miyakawaet al. show that, via interaction with the HIV Gag precursor protein, APC promotes membrane targeting of viral components and cell-to-cell spread of HIV.Kei MiyakawaMayuko NishiSatoko MatsunagaAkiko OkayamaMasaki AnrakuAyumi KudohHisashi HiranoHirokazu KimuraYuko MorikawaNaoki YamamotoAkira OnoAkihide RyoNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Kei Miyakawa Mayuko Nishi Satoko Matsunaga Akiko Okayama Masaki Anraku Ayumi Kudoh Hisashi Hirano Hirokazu Kimura Yuko Morikawa Naoki Yamamoto Akira Ono Akihide Ryo The tumour suppressor APC promotes HIV-1 assembly via interaction with Gag precursor protein
description	The tumour suppressor APC is a multifunctional protein implicated in intracellular localization of mRNAs and WNT signalling. Here, Miyakawaet al. show that, via interaction with the HIV Gag precursor protein, APC promotes membrane targeting of viral components and cell-to-cell spread of HIV.
format	article
author	Kei Miyakawa Mayuko Nishi Satoko Matsunaga Akiko Okayama Masaki Anraku Ayumi Kudoh Hisashi Hirano Hirokazu Kimura Yuko Morikawa Naoki Yamamoto Akira Ono Akihide Ryo
author_facet	Kei Miyakawa Mayuko Nishi Satoko Matsunaga Akiko Okayama Masaki Anraku Ayumi Kudoh Hisashi Hirano Hirokazu Kimura Yuko Morikawa Naoki Yamamoto Akira Ono Akihide Ryo
author_sort	Kei Miyakawa
title	The tumour suppressor APC promotes HIV-1 assembly via interaction with Gag precursor protein
title_short	The tumour suppressor APC promotes HIV-1 assembly via interaction with Gag precursor protein
title_full	The tumour suppressor APC promotes HIV-1 assembly via interaction with Gag precursor protein
title_fullStr	The tumour suppressor APC promotes HIV-1 assembly via interaction with Gag precursor protein
title_full_unstemmed	The tumour suppressor APC promotes HIV-1 assembly via interaction with Gag precursor protein
title_sort	tumour suppressor apc promotes hiv-1 assembly via interaction with gag precursor protein
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/ae209f474cd54f76a8408cf01cef6786
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The tumour suppressor APC promotes HIV-1 assembly via interaction with Gag precursor protein

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