A ligand-specific blockade of the integrin Mac-1 selectively targets pathologic inflammation while maintaining protective host-defense
Integrin-based therapeutics could block inflammatory processes but they also impair host defence, limiting their usefulness. Here the authors report an anti-Mac1 antibody that blocks its interaction with pro-inflammatory ligand CD40L but not other ligands, and show that it can protect against sepsis...
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Nature Portfolio
2018
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oai:doaj.org-article:ae4c48a947914a8f8492c31615ba0c382021-12-02T15:34:28ZA ligand-specific blockade of the integrin Mac-1 selectively targets pathologic inflammation while maintaining protective host-defense10.1038/s41467-018-02896-82041-1723https://doaj.org/article/ae4c48a947914a8f8492c31615ba0c382018-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-02896-8https://doaj.org/toc/2041-1723Integrin-based therapeutics could block inflammatory processes but they also impair host defence, limiting their usefulness. Here the authors report an anti-Mac1 antibody that blocks its interaction with pro-inflammatory ligand CD40L but not other ligands, and show that it can protect against sepsis in mice.Dennis WolfNathaly Anto-MichelHermann BlankenbachAnsgar WiedemannKonrad BuscherJan David HohmannBock LimMarina BäumlAlex MarkiMaximilian MaulerDaniel DuerschmiedZhichao FanHolger WinkelsDaniel SidlerPhilipp DiehlDirk M ZajoncIngo HilgendorfPeter StachonTimoteo MarchiniFlorian WilleckeMaximilian SchellBjörn SommerConstantin von zur MuhlenJochen ReinöhlTeresa GerhardtEdward F. PlowValentin YakubenkoPeter LibbyChristoph BodeKlaus LeyKarlheinz PeterAndreas ZirlikNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-11 (2018) |
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EN |
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Science Q Dennis Wolf Nathaly Anto-Michel Hermann Blankenbach Ansgar Wiedemann Konrad Buscher Jan David Hohmann Bock Lim Marina Bäuml Alex Marki Maximilian Mauler Daniel Duerschmied Zhichao Fan Holger Winkels Daniel Sidler Philipp Diehl Dirk M Zajonc Ingo Hilgendorf Peter Stachon Timoteo Marchini Florian Willecke Maximilian Schell Björn Sommer Constantin von zur Muhlen Jochen Reinöhl Teresa Gerhardt Edward F. Plow Valentin Yakubenko Peter Libby Christoph Bode Klaus Ley Karlheinz Peter Andreas Zirlik A ligand-specific blockade of the integrin Mac-1 selectively targets pathologic inflammation while maintaining protective host-defense |
| description |
Integrin-based therapeutics could block inflammatory processes but they also impair host defence, limiting their usefulness. Here the authors report an anti-Mac1 antibody that blocks its interaction with pro-inflammatory ligand CD40L but not other ligands, and show that it can protect against sepsis in mice. |
| format |
article |
| author |
Dennis Wolf Nathaly Anto-Michel Hermann Blankenbach Ansgar Wiedemann Konrad Buscher Jan David Hohmann Bock Lim Marina Bäuml Alex Marki Maximilian Mauler Daniel Duerschmied Zhichao Fan Holger Winkels Daniel Sidler Philipp Diehl Dirk M Zajonc Ingo Hilgendorf Peter Stachon Timoteo Marchini Florian Willecke Maximilian Schell Björn Sommer Constantin von zur Muhlen Jochen Reinöhl Teresa Gerhardt Edward F. Plow Valentin Yakubenko Peter Libby Christoph Bode Klaus Ley Karlheinz Peter Andreas Zirlik |
| author_facet |
Dennis Wolf Nathaly Anto-Michel Hermann Blankenbach Ansgar Wiedemann Konrad Buscher Jan David Hohmann Bock Lim Marina Bäuml Alex Marki Maximilian Mauler Daniel Duerschmied Zhichao Fan Holger Winkels Daniel Sidler Philipp Diehl Dirk M Zajonc Ingo Hilgendorf Peter Stachon Timoteo Marchini Florian Willecke Maximilian Schell Björn Sommer Constantin von zur Muhlen Jochen Reinöhl Teresa Gerhardt Edward F. Plow Valentin Yakubenko Peter Libby Christoph Bode Klaus Ley Karlheinz Peter Andreas Zirlik |
| author_sort |
Dennis Wolf |
| title |
A ligand-specific blockade of the integrin Mac-1 selectively targets pathologic inflammation while maintaining protective host-defense |
| title_short |
A ligand-specific blockade of the integrin Mac-1 selectively targets pathologic inflammation while maintaining protective host-defense |
| title_full |
A ligand-specific blockade of the integrin Mac-1 selectively targets pathologic inflammation while maintaining protective host-defense |
| title_fullStr |
A ligand-specific blockade of the integrin Mac-1 selectively targets pathologic inflammation while maintaining protective host-defense |
| title_full_unstemmed |
A ligand-specific blockade of the integrin Mac-1 selectively targets pathologic inflammation while maintaining protective host-defense |
| title_sort |
ligand-specific blockade of the integrin mac-1 selectively targets pathologic inflammation while maintaining protective host-defense |
| publisher |
Nature Portfolio |
| publishDate |
2018 |
| url |
https://doaj.org/article/ae4c48a947914a8f8492c31615ba0c38 |
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