Combinatorial entropy behaviour leads to range selective binding in ligand-receptor interactions

Multivalent ligand-receptor interactions enhance binding selectivity in biological systems, and may be exploited to design synthetic systems. Here the authors demonstrate a multivalent behavior where the ability to bind the target occurs when the receptor density is within a specific range.

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Autores principales:	Meng Liu, Azzurra Apriceno, Miguel Sipin, Edoardo Scarpa, Laura Rodriguez-Arco, Alessandro Poma, Gabriele Marchello, Giuseppe Battaglia, Stefano Angioletti-Uberti
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ae5f2342984c4fa3b96a0bc47482a97e
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spelling	oai:doaj.org-article:ae5f2342984c4fa3b96a0bc47482a97e2021-12-02T18:13:46ZCombinatorial entropy behaviour leads to range selective binding in ligand-receptor interactions10.1038/s41467-020-18603-52041-1723https://doaj.org/article/ae5f2342984c4fa3b96a0bc47482a97e2020-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18603-5https://doaj.org/toc/2041-1723Multivalent ligand-receptor interactions enhance binding selectivity in biological systems, and may be exploited to design synthetic systems. Here the authors demonstrate a multivalent behavior where the ability to bind the target occurs when the receptor density is within a specific range.Meng LiuAzzurra ApricenoMiguel SipinEdoardo ScarpaLaura Rodriguez-ArcoAlessandro PomaGabriele MarchelloGiuseppe BattagliaStefano Angioletti-UbertiNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Meng Liu Azzurra Apriceno Miguel Sipin Edoardo Scarpa Laura Rodriguez-Arco Alessandro Poma Gabriele Marchello Giuseppe Battaglia Stefano Angioletti-Uberti Combinatorial entropy behaviour leads to range selective binding in ligand-receptor interactions
description	Multivalent ligand-receptor interactions enhance binding selectivity in biological systems, and may be exploited to design synthetic systems. Here the authors demonstrate a multivalent behavior where the ability to bind the target occurs when the receptor density is within a specific range.
format	article
author	Meng Liu Azzurra Apriceno Miguel Sipin Edoardo Scarpa Laura Rodriguez-Arco Alessandro Poma Gabriele Marchello Giuseppe Battaglia Stefano Angioletti-Uberti
author_facet	Meng Liu Azzurra Apriceno Miguel Sipin Edoardo Scarpa Laura Rodriguez-Arco Alessandro Poma Gabriele Marchello Giuseppe Battaglia Stefano Angioletti-Uberti
author_sort	Meng Liu
title	Combinatorial entropy behaviour leads to range selective binding in ligand-receptor interactions
title_short	Combinatorial entropy behaviour leads to range selective binding in ligand-receptor interactions
title_full	Combinatorial entropy behaviour leads to range selective binding in ligand-receptor interactions
title_fullStr	Combinatorial entropy behaviour leads to range selective binding in ligand-receptor interactions
title_full_unstemmed	Combinatorial entropy behaviour leads to range selective binding in ligand-receptor interactions
title_sort	combinatorial entropy behaviour leads to range selective binding in ligand-receptor interactions
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/ae5f2342984c4fa3b96a0bc47482a97e
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Combinatorial entropy behaviour leads to range selective binding in ligand-receptor interactions

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