The Hsp90 machinery facilitates the transport of diphtheria toxin into human cells

The Hsp90 machinery facilitates the transport of diphtheria toxin into human cells

Abstract Diphtheria toxin kills human cells because it delivers its enzyme domain DTA into their cytosol where it inhibits protein synthesis. After receptor-mediated uptake of the toxin, DTA translocates from acidic endosomes into the cytosol, which might be assisted by host cell factors. Here we in...

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Main Authors: Manuel Schuster, Leonie Schnell, Peter Feigl, Carina Birkhofer, Katharina Mohr, Maurice Roeder, Stefan Carle, Simon Langer, Franziska Tippel, Johannes Buchner, Gunter Fischer, Felix Hausch, Manfred Frick, Carsten Schwan, Klaus Aktories, Cordelia Schiene-Fischer, Holger Barth
Format: article
Language:EN
Published: Nature Portfolio 2017
Subjects:
Medicine
R
Science
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Online Access:https://doaj.org/article/ae633d2015bd44bcb353d2cd6cd6a608
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https://doaj.org/article/ae633d2015bd44bcb353d2cd6cd6a608

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