Gating mechanism of the extracellular entry to the lipid pathway in a TMEM16 scramblase

Some TMEM16 family members are Ca2+-dependent phospholipid scramblases, which also mediate non-selective ion transport; however, the mechanism how lipids permeate through the TMEM16 remains poorly understood. Here, the authors combine biochemical assays and simulations to identify the key steps regu...

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Autores principales:	Byoung-Cheol Lee, George Khelashvili, Maria Falzone, Anant K. Menon, Harel Weinstein, Alessio Accardi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ae6b3950bcc946ad841e6d949d6d90e5
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spelling	oai:doaj.org-article:ae6b3950bcc946ad841e6d949d6d90e52021-12-02T15:34:19ZGating mechanism of the extracellular entry to the lipid pathway in a TMEM16 scramblase10.1038/s41467-018-05724-12041-1723https://doaj.org/article/ae6b3950bcc946ad841e6d949d6d90e52018-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05724-1https://doaj.org/toc/2041-1723Some TMEM16 family members are Ca2+-dependent phospholipid scramblases, which also mediate non-selective ion transport; however, the mechanism how lipids permeate through the TMEM16 remains poorly understood. Here, the authors combine biochemical assays and simulations to identify the key steps regulating lipid movement through the membrane-exposed groove.Byoung-Cheol LeeGeorge KhelashviliMaria FalzoneAnant K. MenonHarel WeinsteinAlessio AccardiNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Byoung-Cheol Lee George Khelashvili Maria Falzone Anant K. Menon Harel Weinstein Alessio Accardi Gating mechanism of the extracellular entry to the lipid pathway in a TMEM16 scramblase
description	Some TMEM16 family members are Ca2+-dependent phospholipid scramblases, which also mediate non-selective ion transport; however, the mechanism how lipids permeate through the TMEM16 remains poorly understood. Here, the authors combine biochemical assays and simulations to identify the key steps regulating lipid movement through the membrane-exposed groove.
format	article
author	Byoung-Cheol Lee George Khelashvili Maria Falzone Anant K. Menon Harel Weinstein Alessio Accardi
author_facet	Byoung-Cheol Lee George Khelashvili Maria Falzone Anant K. Menon Harel Weinstein Alessio Accardi
author_sort	Byoung-Cheol Lee
title	Gating mechanism of the extracellular entry to the lipid pathway in a TMEM16 scramblase
title_short	Gating mechanism of the extracellular entry to the lipid pathway in a TMEM16 scramblase
title_full	Gating mechanism of the extracellular entry to the lipid pathway in a TMEM16 scramblase
title_fullStr	Gating mechanism of the extracellular entry to the lipid pathway in a TMEM16 scramblase
title_full_unstemmed	Gating mechanism of the extracellular entry to the lipid pathway in a TMEM16 scramblase
title_sort	gating mechanism of the extracellular entry to the lipid pathway in a tmem16 scramblase
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/ae6b3950bcc946ad841e6d949d6d90e5
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Gating mechanism of the extracellular entry to the lipid pathway in a TMEM16 scramblase

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