Metronomic delivery of orally available pemetrexed-incorporated colloidal dispersions for boosting tumor-specific immunity

In this study, we developed oral pemetrexed (PMX) for metronomic dosing to enhance antitumor immunity. PMX was electrostatically complexed with positively charged lysine-linked deoxycholic acid (DL) as an intestinal permeation enhancer, forming PMX/DL, to enhance its intestinal permeability. PMX/DL...

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Autores principales: Ruby Maharjan, Laxman Subedi, Rudra Pangeni, Saurav Kumar Jha, Seo Hee Kang, Kwan-Young Chang, Youngro Byun, Jeong Uk Choi, Jin Woo Park
Formato: article
Lenguaje:EN
Publicado: Taylor & Francis Group 2021
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Acceso en línea:https://doaj.org/article/ae87ec3ea3aa4f77beaa8a3f22a6c13f
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