UPF1/SMG7-dependent microRNA-mediated gene regulation

UPF1/SMG7-dependent microRNA-mediated gene regulation

UPF1 mediates the decay of target mRNA in a 3′ untranslated region (UTR)-length-dependent manner. Here the authors reveal that the 3′UTR-length-dependent regulation of UPF1-dependent mRNA decay occurs through EJC-independent but miRNA-dependent regulation.

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Autores principales: Jungyun Park, Jwa-Won Seo, Narae Ahn, Seokju Park, Jungwook Hwang, Jin-Wu Nam
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/aeabc36501bf4d86b4a07be8fc7af2cd
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spelling oai:doaj.org-article:aeabc36501bf4d86b4a07be8fc7af2cd2021-12-02T17:01:40ZUPF1/SMG7-dependent microRNA-mediated gene regulation10.1038/s41467-019-12123-72041-1723https://doaj.org/article/aeabc36501bf4d86b4a07be8fc7af2cd2019-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12123-7https://doaj.org/toc/2041-1723UPF1 mediates the decay of target mRNA in a 3′ untranslated region (UTR)-length-dependent manner. Here the authors reveal that the 3′UTR-length-dependent regulation of UPF1-dependent mRNA decay occurs through EJC-independent but miRNA-dependent regulation.Jungyun ParkJwa-Won SeoNarae AhnSeokju ParkJungwook HwangJin-Wu NamNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Jungyun Park
Jwa-Won Seo
Narae Ahn
Seokju Park
Jungwook Hwang
Jin-Wu Nam
UPF1/SMG7-dependent microRNA-mediated gene regulation
description UPF1 mediates the decay of target mRNA in a 3′ untranslated region (UTR)-length-dependent manner. Here the authors reveal that the 3′UTR-length-dependent regulation of UPF1-dependent mRNA decay occurs through EJC-independent but miRNA-dependent regulation.
format article
author Jungyun Park
Jwa-Won Seo
Narae Ahn
Seokju Park
Jungwook Hwang
Jin-Wu Nam
author_facet Jungyun Park
Jwa-Won Seo
Narae Ahn
Seokju Park
Jungwook Hwang
Jin-Wu Nam
author_sort Jungyun Park
title UPF1/SMG7-dependent microRNA-mediated gene regulation
title_short UPF1/SMG7-dependent microRNA-mediated gene regulation
title_full UPF1/SMG7-dependent microRNA-mediated gene regulation
title_fullStr UPF1/SMG7-dependent microRNA-mediated gene regulation
title_full_unstemmed UPF1/SMG7-dependent microRNA-mediated gene regulation
title_sort upf1/smg7-dependent microrna-mediated gene regulation
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/aeabc36501bf4d86b4a07be8fc7af2cd
work_keys_str_mv AT jungyunpark upf1smg7dependentmicrornamediatedgeneregulation
AT jwawonseo upf1smg7dependentmicrornamediatedgeneregulation
AT naraeahn upf1smg7dependentmicrornamediatedgeneregulation
AT seokjupark upf1smg7dependentmicrornamediatedgeneregulation
AT jungwookhwang upf1smg7dependentmicrornamediatedgeneregulation
AT jinwunam upf1smg7dependentmicrornamediatedgeneregulation
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