The shape of human squalene epoxidase expands the arsenal against cancer

Abstract Squalene epoxidase (also known as squalene monooxygenase, EC 1.14.99.7) is a key rate-limiting enzyme in cholesterol biosynthesis. Anil Padyana and colleagues report the long awaited structure of human squalene epoxidase (SQLE). They solved the crystal structure of the catalytic domain of h...

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Auteurs principaux: Andrew J. Brown, Ngee Kiat Chua, Nieng Yan
Format: article
Langue:EN
Publié: Nature Portfolio 2019
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Accès en ligne:https://doaj.org/article/aef4b715043743b3a89265bef8cffcc9
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