PD-L1 upregulation is associated with activation of the DNA double-strand break repair pathway in patients with colitic cancer

PD-L1 upregulation is associated with activation of the DNA double-strand break repair pathway in patients with colitic cancer

Abstract Ulcerative colitis (UC) is a DNA damage-associated chronic inflammatory disease; the DNA double-strand break (DSB) repair pathway participates in UC-associated dysplasia/colitic cancer carcinogenesis. The DSB/interferon regulatory factor-1 (IRF-1) pathway can induce PD-L1 expression transcr...

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Main Authors: Naoya Ozawa, Takehiko Yokobori, Katsuya Osone, Chika Katayama, Kunihiko Suga, Chika Komine, Yuta Shibasaki, Takuya Shiraishi, Takuhisa Okada, Ryuji Kato, Hiroomi Ogawa, Akihiko Sano, Makoto Sakai, Makoto Sohda, Hitoshi Ojima, Tatsuya Miyazaki, Yoko Motegi, Munenori Ide, Takashi Yao, Hiroyuki Kuwano, Ken Shirabe, Hiroshi Saeki
Format: article
Language:EN
Published: Nature Portfolio 2021
Subjects:
Medicine
R
Science
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Online Access:https://doaj.org/article/af1b22a145e34167b4094d6666a0d50f
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