Stabilized coronavirus spike stem elicits a broadly protective antibody

Stabilized coronavirus spike stem elicits a broadly protective antibody

Summary: Current coronavirus (CoV) vaccines primarily target immunodominant epitopes in the S1 subunit, which are poorly conserved and susceptible to escape mutations, thus threatening vaccine efficacy. Here, we use structure-guided protein engineering to remove the S1 subunit from the Middle East r...

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Autores principales: Ching-Lin Hsieh, Anne P. Werner, Sarah R. Leist, Laura J. Stevens, Ester Falconer, Jory A. Goldsmith, Chia-Wei Chou, Olubukola M. Abiona, Ande West, Kathryn Westendorf, Krithika Muthuraman, Ethan J. Fritch, Kenneth H. Dinnon, III, Alexandra Schäfer, Mark R. Denison, James D. Chappell, Ralph S. Baric, Barney S. Graham, Kizzmekia S. Corbett, Jason S. McLellan
Formato: article
Lenguaje:EN
Publicado: Elsevier 2021
Materias:
coronaviruses (CoV)
spike (S) glycoprotein
stem stabilization
cross-reactivity
protective antibodies
protective antigens
Biology (General)
QH301-705.5
Acceso en línea:https://doaj.org/article/af2791637eea401ba71a9731ca3cb5c0
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https://doaj.org/article/af2791637eea401ba71a9731ca3cb5c0

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