New Bioactive Fused Triazolothiadiazoles as Bcl-2-Targeted Anticancer Agents

A series of 3-(6-substituted phenyl-[1,2,4]-triazolo[3,4-b]-[1,3,4]-thiadiazol-3-yl)-1H-indoles (<b>5a</b>–<b>l</b>) were designed, synthesized and evaluated for anti-apoptotic Bcl-2-inhibitory activity. Synthesis of the target compounds was readily accomplished through a rea...

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Autores principales: Rania Hamdy, Arwyn T. Jones, Mohamed El-Sadek, Alshaimaa M. Hamoda, Sarra B. Shakartalla, Zainab M. AL Shareef, Sameh S. M. Soliman, Andrew D. Westwell
Formato: article
Lenguaje:EN
Publicado: MDPI AG 2021
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Acceso en línea:https://doaj.org/article/af2a65ec3d3641878ea076cea3f09a8a
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