Synergistic effects of ion transporter and MAP kinase pathway inhibitors in melanoma

Synergistic effects of ion transporter and MAP kinase pathway inhibitors in melanoma

Treatment responses of melanoma patients to MAPK pathway inhibitors are often limited. Here, the authors show that combining cardiac glycosides with MAPK inhibitors improves tumor regression by inducing intracellular acidification, mitochondrial calcium dysregulation, ATP depletion, and cell death.

Guardado en:
Detalles Bibliográficos
Autores principales: Ugur Eskiocak, Vijayashree Ramesh, Jennifer G. Gill, Zhiyu Zhao, Stacy W. Yuan, Meng Wang, Travis Vandergriff, Mark Shackleton, Elsa Quintana, Arthur E. Frankel, Timothy M. Johnson, Ralph J. DeBerardinis, Sean J. Morrison
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/af2b613ebe124fc991b554202905400b
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Internet

https://doaj.org/article/af2b613ebe124fc991b554202905400b

Ejemplares similares