Synergistic effects of ion transporter and MAP kinase pathway inhibitors in melanoma

Treatment responses of melanoma patients to MAPK pathway inhibitors are often limited. Here, the authors show that combining cardiac glycosides with MAPK inhibitors improves tumor regression by inducing intracellular acidification, mitochondrial calcium dysregulation, ATP depletion, and cell death.

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Autores principales:	Ugur Eskiocak, Vijayashree Ramesh, Jennifer G. Gill, Zhiyu Zhao, Stacy W. Yuan, Meng Wang, Travis Vandergriff, Mark Shackleton, Elsa Quintana, Arthur E. Frankel, Timothy M. Johnson, Ralph J. DeBerardinis, Sean J. Morrison
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/af2b613ebe124fc991b554202905400b
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spelling	oai:doaj.org-article:af2b613ebe124fc991b554202905400b2021-12-02T17:32:19ZSynergistic effects of ion transporter and MAP kinase pathway inhibitors in melanoma10.1038/ncomms123362041-1723https://doaj.org/article/af2b613ebe124fc991b554202905400b2016-08-01T00:00:00Zhttps://doi.org/10.1038/ncomms12336https://doaj.org/toc/2041-1723Treatment responses of melanoma patients to MAPK pathway inhibitors are often limited. Here, the authors show that combining cardiac glycosides with MAPK inhibitors improves tumor regression by inducing intracellular acidification, mitochondrial calcium dysregulation, ATP depletion, and cell death.Ugur EskiocakVijayashree RameshJennifer G. GillZhiyu ZhaoStacy W. YuanMeng WangTravis VandergriffMark ShackletonElsa QuintanaArthur E. FrankelTimothy M. JohnsonRalph J. DeBerardinisSean J. MorrisonNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-19 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ugur Eskiocak Vijayashree Ramesh Jennifer G. Gill Zhiyu Zhao Stacy W. Yuan Meng Wang Travis Vandergriff Mark Shackleton Elsa Quintana Arthur E. Frankel Timothy M. Johnson Ralph J. DeBerardinis Sean J. Morrison Synergistic effects of ion transporter and MAP kinase pathway inhibitors in melanoma
description	Treatment responses of melanoma patients to MAPK pathway inhibitors are often limited. Here, the authors show that combining cardiac glycosides with MAPK inhibitors improves tumor regression by inducing intracellular acidification, mitochondrial calcium dysregulation, ATP depletion, and cell death.
format	article
author	Ugur Eskiocak Vijayashree Ramesh Jennifer G. Gill Zhiyu Zhao Stacy W. Yuan Meng Wang Travis Vandergriff Mark Shackleton Elsa Quintana Arthur E. Frankel Timothy M. Johnson Ralph J. DeBerardinis Sean J. Morrison
author_facet	Ugur Eskiocak Vijayashree Ramesh Jennifer G. Gill Zhiyu Zhao Stacy W. Yuan Meng Wang Travis Vandergriff Mark Shackleton Elsa Quintana Arthur E. Frankel Timothy M. Johnson Ralph J. DeBerardinis Sean J. Morrison
author_sort	Ugur Eskiocak
title	Synergistic effects of ion transporter and MAP kinase pathway inhibitors in melanoma
title_short	Synergistic effects of ion transporter and MAP kinase pathway inhibitors in melanoma
title_full	Synergistic effects of ion transporter and MAP kinase pathway inhibitors in melanoma
title_fullStr	Synergistic effects of ion transporter and MAP kinase pathway inhibitors in melanoma
title_full_unstemmed	Synergistic effects of ion transporter and MAP kinase pathway inhibitors in melanoma
title_sort	synergistic effects of ion transporter and map kinase pathway inhibitors in melanoma
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/af2b613ebe124fc991b554202905400b
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_version_	1718380327951400960

Synergistic effects of ion transporter and MAP kinase pathway inhibitors in melanoma

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