Synergistic effects of ion transporter and MAP kinase pathway inhibitors in melanoma

Treatment responses of melanoma patients to MAPK pathway inhibitors are often limited. Here, the authors show that combining cardiac glycosides with MAPK inhibitors improves tumor regression by inducing intracellular acidification, mitochondrial calcium dysregulation, ATP depletion, and cell death.

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Detalles Bibliográficos
Autores principales: Ugur Eskiocak, Vijayashree Ramesh, Jennifer G. Gill, Zhiyu Zhao, Stacy W. Yuan, Meng Wang, Travis Vandergriff, Mark Shackleton, Elsa Quintana, Arthur E. Frankel, Timothy M. Johnson, Ralph J. DeBerardinis, Sean J. Morrison
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
Materias:
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Acceso en línea:https://doaj.org/article/af2b613ebe124fc991b554202905400b
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