Zinc regulates ERp44-dependent protein quality control in the early secretory pathway

Zinc ions (Zn2+) are imported by Golgi-resident transporters but the function of zinc in the early secretory pathway has remained unknown. Here the authors find that Zn2+ regulates protein quality control in the early secretory pathway by demonstrating that the pH-sensitive chaperone ERp44 binds Zn2...

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Autores principales:	Satoshi Watanabe, Yuta Amagai, Sara Sannino, Tiziana Tempio, Tiziana Anelli, Manami Harayama, Shoji Masui, Ilaria Sorrentino, Momo Yamada, Roberto Sitia, Kenji Inaba
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/af4ed761dc184e4d9ee05ac87e0596a8
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spelling	oai:doaj.org-article:af4ed761dc184e4d9ee05ac87e0596a82021-12-02T15:36:05ZZinc regulates ERp44-dependent protein quality control in the early secretory pathway10.1038/s41467-019-08429-12041-1723https://doaj.org/article/af4ed761dc184e4d9ee05ac87e0596a82019-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08429-1https://doaj.org/toc/2041-1723Zinc ions (Zn2+) are imported by Golgi-resident transporters but the function of zinc in the early secretory pathway has remained unknown. Here the authors find that Zn2+ regulates protein quality control in the early secretory pathway by demonstrating that the pH-sensitive chaperone ERp44 binds Zn2+ and solving the Zn2+-bound ERp44 structure.Satoshi WatanabeYuta AmagaiSara SanninoTiziana TempioTiziana AnelliManami HarayamaShoji MasuiIlaria SorrentinoMomo YamadaRoberto SitiaKenji InabaNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Satoshi Watanabe Yuta Amagai Sara Sannino Tiziana Tempio Tiziana Anelli Manami Harayama Shoji Masui Ilaria Sorrentino Momo Yamada Roberto Sitia Kenji Inaba Zinc regulates ERp44-dependent protein quality control in the early secretory pathway
description	Zinc ions (Zn2+) are imported by Golgi-resident transporters but the function of zinc in the early secretory pathway has remained unknown. Here the authors find that Zn2+ regulates protein quality control in the early secretory pathway by demonstrating that the pH-sensitive chaperone ERp44 binds Zn2+ and solving the Zn2+-bound ERp44 structure.
format	article
author	Satoshi Watanabe Yuta Amagai Sara Sannino Tiziana Tempio Tiziana Anelli Manami Harayama Shoji Masui Ilaria Sorrentino Momo Yamada Roberto Sitia Kenji Inaba
author_facet	Satoshi Watanabe Yuta Amagai Sara Sannino Tiziana Tempio Tiziana Anelli Manami Harayama Shoji Masui Ilaria Sorrentino Momo Yamada Roberto Sitia Kenji Inaba
author_sort	Satoshi Watanabe
title	Zinc regulates ERp44-dependent protein quality control in the early secretory pathway
title_short	Zinc regulates ERp44-dependent protein quality control in the early secretory pathway
title_full	Zinc regulates ERp44-dependent protein quality control in the early secretory pathway
title_fullStr	Zinc regulates ERp44-dependent protein quality control in the early secretory pathway
title_full_unstemmed	Zinc regulates ERp44-dependent protein quality control in the early secretory pathway
title_sort	zinc regulates erp44-dependent protein quality control in the early secretory pathway
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/af4ed761dc184e4d9ee05ac87e0596a8
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Zinc regulates ERp44-dependent protein quality control in the early secretory pathway

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