Zinc regulates ERp44-dependent protein quality control in the early secretory pathway

Zinc ions (Zn2+) are imported by Golgi-resident transporters but the function of zinc in the early secretory pathway has remained unknown. Here the authors find that Zn2+ regulates protein quality control in the early secretory pathway by demonstrating that the pH-sensitive chaperone ERp44 binds Zn2...

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Autores principales: Satoshi Watanabe, Yuta Amagai, Sara Sannino, Tiziana Tempio, Tiziana Anelli, Manami Harayama, Shoji Masui, Ilaria Sorrentino, Momo Yamada, Roberto Sitia, Kenji Inaba
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/af4ed761dc184e4d9ee05ac87e0596a8
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