Calcium Binding Protein Ncs1 Is Calcineurin Regulated in <named-content content-type="genus-species">Cryptococcus neoformans</named-content> and Essential for Cell Division and Virulence

Calcium Binding Protein Ncs1 Is Calcineurin Regulated in <named-content content-type="genus-species">Cryptococcus neoformans</named-content> and Essential for Cell Division and Virulence

ABSTRACT Intracellular calcium (Ca2+) is crucial for signal transduction in Cryptococcus neoformans, the major cause of fatal fungal meningitis. The calcineurin pathway is the only Ca2+-requiring signaling cascade implicated in cryptococcal stress adaptation and virulence, with Ca2+ binding mediated...

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Main Authors: Eamim Daidrê Squizani, Júlia Catarina Vieira Reuwsaat, Sophie Lev, Heryk Motta, Julia Sperotto, Keren Kaufman-Francis, Desmarini Desmarini, Marilene Henning Vainstein, Charley Christian Staats, Julianne T. Djordjevic, Lívia Kmetzsch
Format: article
Language:EN
Published: American Society for Microbiology 2020
Subjects:
calcium binding protein
calcium sensor
Cryptococcus neoformans
calcium signaling
Microbiology
QR1-502
Online Access:https://doaj.org/article/af512a2c632e48f29809129f84c64afb
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https://doaj.org/article/af512a2c632e48f29809129f84c64afb

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