Structural basis of phosphatidylcholine recognition by the C2–domain of cytosolic phospholipase A2α

Structural basis of phosphatidylcholine recognition by the C2–domain of cytosolic phospholipase A2α

Ca2+-stimulated translocation of cytosolic phospholipase A2α (cPLA2α) to the Golgi induces arachidonic acid production, the rate-limiting step in pro-inflammatory eicosanoid synthesis. Structural insights into the cPLA2α preference for phosphatidylcholine (PC)-enriched membranes have remained elusiv...

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Bibliographic Details
Main Authors: Yoshinori Hirano, Yong-Guang Gao, Daniel J Stephenson, Ngoc T Vu, Lucy Malinina, Dhirendra K Simanshu, Charles E Chalfant, Dinshaw J Patel, Rhoderick E Brown
Format: article
Language:EN
Published: eLife Sciences Publications Ltd 2019
Subjects:
C2-domain of cytoplasmic phospholipase A2 alpha
structural mapping of phosphatidylcholine binding site
structure-function analyses
Medicine
R
Science
Q
Biology (General)
QH301-705.5
Online Access:https://doaj.org/article/af6a1b2fae9e4f1fa435261f48886fe1
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https://doaj.org/article/af6a1b2fae9e4f1fa435261f48886fe1

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