Orientation-dependent Dxz4 contacts shape the 3D structure of the inactive X chromosome

The inactive X chromosome condenses into a bipartite structure. Here the authors use cells with allelic deletions or inversions to show that the Dxz4 locus is necessary to maintain the bipartite structure and that Dxz4 orientation controls the distribution of contacts on the inactive X chromosome.

Guardado en:
Detalles Bibliográficos
Autores principales: G. Bonora, X. Deng, H. Fang, V. Ramani, R. Qiu, J. B. Berletch, G. N. Filippova, Z. Duan, J. Shendure, W. S. Noble, C. M. Disteche
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
Materias:
Q
Acceso en línea:https://doaj.org/article/afd44e04d74f45258dc5ec7a69e31b59
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!