Oscillations of Delta-like1 regulate the balance between differentiation and maintenance of muscle stem cells

The cell source and dynamics of Notch ligands during the regulation of muscle stem cells is unclear. Here, the authors show that the Notch ligand Dll1 has to oscillate in order to control the balance between self-renewal and differentiation of muscle stem cells, with Hes1 acting as transcriptional p...

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Auteurs principaux: Yao Zhang, Ines Lahmann, Katharina Baum, Hiromi Shimojo, Philippos Mourikis, Jana Wolf, Ryoichiro Kageyama, Carmen Birchmeier
Format: article
Langue:EN
Publié: Nature Portfolio 2021
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Accès en ligne:https://doaj.org/article/afeed375ae874570b42ac52637193643
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