Oscillations of Delta-like1 regulate the balance between differentiation and maintenance of muscle stem cells

The cell source and dynamics of Notch ligands during the regulation of muscle stem cells is unclear. Here, the authors show that the Notch ligand Dll1 has to oscillate in order to control the balance between self-renewal and differentiation of muscle stem cells, with Hes1 acting as transcriptional p...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Yao Zhang, Ines Lahmann, Katharina Baum, Hiromi Shimojo, Philippos Mourikis, Jana Wolf, Ryoichiro Kageyama, Carmen Birchmeier
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/afeed375ae874570b42ac52637193643
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:afeed375ae874570b42ac52637193643
record_format	dspace
spelling	oai:doaj.org-article:afeed375ae874570b42ac526371936432021-12-02T13:33:02ZOscillations of Delta-like1 regulate the balance between differentiation and maintenance of muscle stem cells10.1038/s41467-021-21631-42041-1723https://doaj.org/article/afeed375ae874570b42ac526371936432021-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21631-4https://doaj.org/toc/2041-1723The cell source and dynamics of Notch ligands during the regulation of muscle stem cells is unclear. Here, the authors show that the Notch ligand Dll1 has to oscillate in order to control the balance between self-renewal and differentiation of muscle stem cells, with Hes1 acting as transcriptional pacemaker for the oscillatory network.Yao ZhangInes LahmannKatharina BaumHiromi ShimojoPhilippos MourikisJana WolfRyoichiro KageyamaCarmen BirchmeierNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yao Zhang Ines Lahmann Katharina Baum Hiromi Shimojo Philippos Mourikis Jana Wolf Ryoichiro Kageyama Carmen Birchmeier Oscillations of Delta-like1 regulate the balance between differentiation and maintenance of muscle stem cells
description	The cell source and dynamics of Notch ligands during the regulation of muscle stem cells is unclear. Here, the authors show that the Notch ligand Dll1 has to oscillate in order to control the balance between self-renewal and differentiation of muscle stem cells, with Hes1 acting as transcriptional pacemaker for the oscillatory network.
format	article
author	Yao Zhang Ines Lahmann Katharina Baum Hiromi Shimojo Philippos Mourikis Jana Wolf Ryoichiro Kageyama Carmen Birchmeier
author_facet	Yao Zhang Ines Lahmann Katharina Baum Hiromi Shimojo Philippos Mourikis Jana Wolf Ryoichiro Kageyama Carmen Birchmeier
author_sort	Yao Zhang
title	Oscillations of Delta-like1 regulate the balance between differentiation and maintenance of muscle stem cells
title_short	Oscillations of Delta-like1 regulate the balance between differentiation and maintenance of muscle stem cells
title_full	Oscillations of Delta-like1 regulate the balance between differentiation and maintenance of muscle stem cells
title_fullStr	Oscillations of Delta-like1 regulate the balance between differentiation and maintenance of muscle stem cells
title_full_unstemmed	Oscillations of Delta-like1 regulate the balance between differentiation and maintenance of muscle stem cells
title_sort	oscillations of delta-like1 regulate the balance between differentiation and maintenance of muscle stem cells
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/afeed375ae874570b42ac52637193643
work_keys_str_mv	AT yaozhang oscillationsofdeltalike1regulatethebalancebetweendifferentiationandmaintenanceofmusclestemcells AT ineslahmann oscillationsofdeltalike1regulatethebalancebetweendifferentiationandmaintenanceofmusclestemcells AT katharinabaum oscillationsofdeltalike1regulatethebalancebetweendifferentiationandmaintenanceofmusclestemcells AT hiromishimojo oscillationsofdeltalike1regulatethebalancebetweendifferentiationandmaintenanceofmusclestemcells AT philipposmourikis oscillationsofdeltalike1regulatethebalancebetweendifferentiationandmaintenanceofmusclestemcells AT janawolf oscillationsofdeltalike1regulatethebalancebetweendifferentiationandmaintenanceofmusclestemcells AT ryoichirokageyama oscillationsofdeltalike1regulatethebalancebetweendifferentiationandmaintenanceofmusclestemcells AT carmenbirchmeier oscillationsofdeltalike1regulatethebalancebetweendifferentiationandmaintenanceofmusclestemcells
_version_	1718392876042289152

Oscillations of Delta-like1 regulate the balance between differentiation and maintenance of muscle stem cells

Ejemplares similares