Histone demethylase JMJD1C is phosphorylated by mTOR to activate de novo lipogenesis

In response to insulin, liver cells increase de novo lipogenesis via the transcription factors USF-1 and SREBP. Here the authors show that USF-1 recruits JMJD1C, after its phosphorylation by mTOR, to lipogenic promoters where JMJD1C demethylates histone H3, contributing to lipogenesis by an epigenet...

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Autores principales: Jose A. Viscarra, Yuhui Wang, Hai P. Nguyen, Yoon Gi Choi, Hei Sook Sul
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/b00b481391d4487aa57db0dfdc9af5fd
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