Histone demethylase JMJD1C is phosphorylated by mTOR to activate de novo lipogenesis

In response to insulin, liver cells increase de novo lipogenesis via the transcription factors USF-1 and SREBP. Here the authors show that USF-1 recruits JMJD1C, after its phosphorylation by mTOR, to lipogenic promoters where JMJD1C demethylates histone H3, contributing to lipogenesis by an epigenet...

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Main Authors:	Jose A. Viscarra, Yuhui Wang, Hai P. Nguyen, Yoon Gi Choi, Hei Sook Sul
Format:	article
Language:	EN
Published:	Nature Portfolio 2020
Subjects:	Science Q
Online Access:	https://doaj.org/article/b00b481391d4487aa57db0dfdc9af5fd
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spelling	oai:doaj.org-article:b00b481391d4487aa57db0dfdc9af5fd2021-12-02T14:41:04ZHistone demethylase JMJD1C is phosphorylated by mTOR to activate de novo lipogenesis10.1038/s41467-020-14617-12041-1723https://doaj.org/article/b00b481391d4487aa57db0dfdc9af5fd2020-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-14617-1https://doaj.org/toc/2041-1723In response to insulin, liver cells increase de novo lipogenesis via the transcription factors USF-1 and SREBP. Here the authors show that USF-1 recruits JMJD1C, after its phosphorylation by mTOR, to lipogenic promoters where JMJD1C demethylates histone H3, contributing to lipogenesis by an epigenetic mechanism.Jose A. ViscarraYuhui WangHai P. NguyenYoon Gi ChoiHei Sook SulNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jose A. Viscarra Yuhui Wang Hai P. Nguyen Yoon Gi Choi Hei Sook Sul Histone demethylase JMJD1C is phosphorylated by mTOR to activate de novo lipogenesis
description	In response to insulin, liver cells increase de novo lipogenesis via the transcription factors USF-1 and SREBP. Here the authors show that USF-1 recruits JMJD1C, after its phosphorylation by mTOR, to lipogenic promoters where JMJD1C demethylates histone H3, contributing to lipogenesis by an epigenetic mechanism.
format	article
author	Jose A. Viscarra Yuhui Wang Hai P. Nguyen Yoon Gi Choi Hei Sook Sul
author_facet	Jose A. Viscarra Yuhui Wang Hai P. Nguyen Yoon Gi Choi Hei Sook Sul
author_sort	Jose A. Viscarra
title	Histone demethylase JMJD1C is phosphorylated by mTOR to activate de novo lipogenesis
title_short	Histone demethylase JMJD1C is phosphorylated by mTOR to activate de novo lipogenesis
title_full	Histone demethylase JMJD1C is phosphorylated by mTOR to activate de novo lipogenesis
title_fullStr	Histone demethylase JMJD1C is phosphorylated by mTOR to activate de novo lipogenesis
title_full_unstemmed	Histone demethylase JMJD1C is phosphorylated by mTOR to activate de novo lipogenesis
title_sort	histone demethylase jmjd1c is phosphorylated by mtor to activate de novo lipogenesis
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/b00b481391d4487aa57db0dfdc9af5fd
work_keys_str_mv	AT joseaviscarra histonedemethylasejmjd1cisphosphorylatedbymtortoactivatedenovolipogenesis AT yuhuiwang histonedemethylasejmjd1cisphosphorylatedbymtortoactivatedenovolipogenesis AT haipnguyen histonedemethylasejmjd1cisphosphorylatedbymtortoactivatedenovolipogenesis AT yoongichoi histonedemethylasejmjd1cisphosphorylatedbymtortoactivatedenovolipogenesis AT heisooksul histonedemethylasejmjd1cisphosphorylatedbymtortoactivatedenovolipogenesis
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Histone demethylase JMJD1C is phosphorylated by mTOR to activate de novo lipogenesis

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