Clitocine reversal of P-glycoprotein associated multi-drug resistance through down-regulation of transcription factor NF-κB in R-HepG2 cell line.

Clitocine reversal of P-glycoprotein associated multi-drug resistance through down-regulation of transcription factor NF-κB in R-HepG2 cell line.

Multidrug resistance (MDR) is one of the major reasons for failure in cancer chemotherapy and its suppression may increase the efficacy of therapy. The human multidrug resistance 1 (MDR1) gene encodes the plasma membrane P-glycoprotein (P-gp) that pumps various anti-cancer agents out of the cancer c...

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Main Authors: Jianguo Sun, Chilam Au Yeung, Ngai Na Co, Tsun Yee Tsang, Esmond Yau, Kewang Luo, Ping Wu, Judy Chan Yuet Wa, Kwok-Pui Fung, Tim-Tak Kwok, Feiyan Liu
Format: article
Language:EN
Published: Public Library of Science (PLoS) 2012
Subjects:
Medicine
R
Science
Q
Online Access:https://doaj.org/article/b018735ff0dd4423a12b0ecc3e30b89c
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