Contrasting Function of Structured N-Terminal and Unstructured C-Terminal Segments of <italic toggle="yes">Mycobacterium tuberculosis</italic> PPE37 Protein

Contrasting Function of Structured N-Terminal and Unstructured C-Terminal Segments of <italic toggle="yes">Mycobacterium tuberculosis</italic> PPE37 Protein

ABSTRACT Pathogens frequently employ eukaryotic linear motif (ELM)-rich intrinsically disordered proteins (IDPs) to perturb and hijack host cell networks for a productive infection. Mycobacterium tuberculosis has a relatively high percentage of IDPs in its proteome, the significance of which is not...

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Main Authors: Javeed Ahmad, Aisha Farhana, Rita Pancsa, Simran Kaur Arora, Alagiri Srinivasan, Anil Kumar Tyagi, Madan Mohan Babu, Nasreen Zafar Ehtesham, Seyed Ehtesham Hasnain
Format: article
Language:EN
Published: American Society for Microbiology 2018
Subjects:
apoptosis
eukaryotic linear motifs
intrinsically disordered regions
molecular mimicry
nuclear localization signal
tolerogenic immune cells
Microbiology
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Online Access:https://doaj.org/article/b0755ae2309d45efba5fd88f40d1044f
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https://doaj.org/article/b0755ae2309d45efba5fd88f40d1044f

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