Drosophila H2Av negatively regulates the activity of the IMD pathway via facilitating Relish SUMOylation.

Insects depend on the innate immune response for defense against a wide array of pathogens. Central to Drosophila immunity are antimicrobial peptides (AMPs), released into circulation when pathogens trigger either of the two widely studied signal pathways, Toll or IMD. The Toll pathway responds to i...

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Autores principales: Ruijuan Tang, Wuren Huang, Jingmin Guan, Qiuning Liu, Brenda T Beerntsen, Erjun Ling
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2021
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Acceso en línea:https://doaj.org/article/b077b047fbe34e54a9abe3d1ffed193d
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