Specification of haematopoietic stem cell fate via modulation of mitochondrial activity

Haematopoietic stem cells rely on glycolysis for their energy demands but whether this affects their fate is unknown. Here, the authors show that forcing the cells to rely on glycolysis is important for self-renewal and that this involves a reduction in mitochondrial mass.

Guardado en:

Detalles Bibliográficos
Autores principales:	Nicola Vannini, Mukul Girotra, Olaia Naveiras, Gennady Nikitin, Vasco Campos, Sonja Giger, Aline Roch, Johan Auwerx, Matthias P. Lutolf
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b081f3f436004a1183c52fe48a38b2c1
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:b081f3f436004a1183c52fe48a38b2c1
record_format	dspace
spelling	oai:doaj.org-article:b081f3f436004a1183c52fe48a38b2c12021-12-02T17:33:08ZSpecification of haematopoietic stem cell fate via modulation of mitochondrial activity10.1038/ncomms131252041-1723https://doaj.org/article/b081f3f436004a1183c52fe48a38b2c12016-10-01T00:00:00Zhttps://doi.org/10.1038/ncomms13125https://doaj.org/toc/2041-1723Haematopoietic stem cells rely on glycolysis for their energy demands but whether this affects their fate is unknown. Here, the authors show that forcing the cells to rely on glycolysis is important for self-renewal and that this involves a reduction in mitochondrial mass.Nicola VanniniMukul GirotraOlaia NaveirasGennady NikitinVasco CamposSonja GigerAline RochJohan AuwerxMatthias P. LutolfNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-9 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Nicola Vannini Mukul Girotra Olaia Naveiras Gennady Nikitin Vasco Campos Sonja Giger Aline Roch Johan Auwerx Matthias P. Lutolf Specification of haematopoietic stem cell fate via modulation of mitochondrial activity
description	Haematopoietic stem cells rely on glycolysis for their energy demands but whether this affects their fate is unknown. Here, the authors show that forcing the cells to rely on glycolysis is important for self-renewal and that this involves a reduction in mitochondrial mass.
format	article
author	Nicola Vannini Mukul Girotra Olaia Naveiras Gennady Nikitin Vasco Campos Sonja Giger Aline Roch Johan Auwerx Matthias P. Lutolf
author_facet	Nicola Vannini Mukul Girotra Olaia Naveiras Gennady Nikitin Vasco Campos Sonja Giger Aline Roch Johan Auwerx Matthias P. Lutolf
author_sort	Nicola Vannini
title	Specification of haematopoietic stem cell fate via modulation of mitochondrial activity
title_short	Specification of haematopoietic stem cell fate via modulation of mitochondrial activity
title_full	Specification of haematopoietic stem cell fate via modulation of mitochondrial activity
title_fullStr	Specification of haematopoietic stem cell fate via modulation of mitochondrial activity
title_full_unstemmed	Specification of haematopoietic stem cell fate via modulation of mitochondrial activity
title_sort	specification of haematopoietic stem cell fate via modulation of mitochondrial activity
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/b081f3f436004a1183c52fe48a38b2c1
work_keys_str_mv	AT nicolavannini specificationofhaematopoieticstemcellfateviamodulationofmitochondrialactivity AT mukulgirotra specificationofhaematopoieticstemcellfateviamodulationofmitochondrialactivity AT olaianaveiras specificationofhaematopoieticstemcellfateviamodulationofmitochondrialactivity AT gennadynikitin specificationofhaematopoieticstemcellfateviamodulationofmitochondrialactivity AT vascocampos specificationofhaematopoieticstemcellfateviamodulationofmitochondrialactivity AT sonjagiger specificationofhaematopoieticstemcellfateviamodulationofmitochondrialactivity AT alineroch specificationofhaematopoieticstemcellfateviamodulationofmitochondrialactivity AT johanauwerx specificationofhaematopoieticstemcellfateviamodulationofmitochondrialactivity AT matthiasplutolf specificationofhaematopoieticstemcellfateviamodulationofmitochondrialactivity
_version_	1718380083280871424

Specification of haematopoietic stem cell fate via modulation of mitochondrial activity

Ejemplares similares