Effect of metformin treatment and its time of administration on joint capsular fibrosis induced by mouse knee immobilization

Abstract Joint contracture leads to major patient discomfort. Metformin, one of the most extensively used oral drugs against type 2 diabetes has recently been found to suppress tissue fibrosis as well. However, its role in suppressing tissue fibrosis in joint contractures remains unknown. In this st...

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Autores principales: Kotaro Tokuda, Yoshiaki Yamanaka, Yosuke Mano, Manabu Tsukamoto, Takafumi Tajima, Hitoshi Suzuki, Makoto Kawasaki, Soshi Uchida, Eiichiro Nakamura, Ke-Yong Wang, Akinori Sakai
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/b08d867773d44dbdad29a543bad64c9e
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