Compact modeling of allosteric multisite proteins: application to a cell size checkpoint.

We explore a framework to model the dose response of allosteric multisite phosphorylation proteins using a single auxiliary variable. This reduction can closely replicate the steady state behavior of detailed multisite systems such as the Monod-Wyman-Changeux allosteric model or rule-based models. O...

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Autores principales: Germán Enciso, Douglas R Kellogg, Arturo Vargas
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2014
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Acceso en línea:https://doaj.org/article/b0936ddefa9d40008cfde4d6b7214a8f
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