Compact modeling of allosteric multisite proteins: application to a cell size checkpoint.
We explore a framework to model the dose response of allosteric multisite phosphorylation proteins using a single auxiliary variable. This reduction can closely replicate the steady state behavior of detailed multisite systems such as the Monod-Wyman-Changeux allosteric model or rule-based models. O...
Guardado en:
Autores principales: | Germán Enciso, Douglas R Kellogg, Arturo Vargas |
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Formato: | article |
Lenguaje: | EN |
Publicado: |
Public Library of Science (PLoS)
2014
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Materias: | |
Acceso en línea: | https://doaj.org/article/b0936ddefa9d40008cfde4d6b7214a8f |
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