Predicting transcriptional activity of multiple site p53 mutants based on hybrid properties.

As an important tumor suppressor protein, reactivate mutated p53 was found in many kinds of human cancers and that restoring active p53 would lead to tumor regression. In this work, we developed a new computational method to predict the transcriptional activity for one-, two-, three- and four-site p...

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Autores principales: Tao Huang, Shen Niu, Zhongping Xu, Yun Huang, Xiangyin Kong, Yu-Dong Cai, Kuo-Chen Chou
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2011
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Acceso en línea:https://doaj.org/article/b0939d94abdd4b6782539087cdd4a629
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