Simulating reading acquisition: The link between reading outcome and multimodal brain signatures of letter–speech sound learning in prereaders

Abstract During reading acquisition, neural reorganization of the human brain facilitates the integration of letters and speech sounds, which enables successful reading. Neuroimaging and behavioural studies have established that impaired audiovisual integration of letters and speech sounds is a core...

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Autores principales:	Iliana I. Karipidis, Georgette Pleisch, Daniel Brandeis, Alexander Roth, Martina Röthlisberger, Maya Schneebeli, Susanne Walitza, Silvia Brem
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b09daeef335e4262bd7a65b2e27853b2
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spelling	oai:doaj.org-article:b09daeef335e4262bd7a65b2e27853b22021-12-02T11:41:25ZSimulating reading acquisition: The link between reading outcome and multimodal brain signatures of letter–speech sound learning in prereaders10.1038/s41598-018-24909-82045-2322https://doaj.org/article/b09daeef335e4262bd7a65b2e27853b22018-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-24909-8https://doaj.org/toc/2045-2322Abstract During reading acquisition, neural reorganization of the human brain facilitates the integration of letters and speech sounds, which enables successful reading. Neuroimaging and behavioural studies have established that impaired audiovisual integration of letters and speech sounds is a core deficit in individuals with developmental dyslexia. This longitudinal study aimed to identify neural and behavioural markers of audiovisual integration that are related to future reading fluency. We simulated the first step of reading acquisition by performing artificial-letter training with prereading children at risk for dyslexia. Multiple logistic regressions revealed that our training provides new precursors of reading fluency at the beginning of reading acquisition. In addition, an event-related potential around 400 ms and functional magnetic resonance imaging activation patterns in the left planum temporale to audiovisual correspondences improved cross-validated prediction of future poor readers. Finally, an exploratory analysis combining simultaneously acquired electroencephalography and hemodynamic data suggested that modulation of temporoparietal brain regions depended on future reading skills. The multimodal approach demonstrates neural adaptations to audiovisual integration in the developing brain that are related to reading outcome. Despite potential limitations arising from the restricted sample size, our results may have promising implications both for identifying poor-reading children and for monitoring early interventions.Iliana I. KaripidisGeorgette PleischDaniel BrandeisAlexander RothMartina RöthlisbergerMaya SchneebeliSusanne WalitzaSilvia BremNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Iliana I. Karipidis Georgette Pleisch Daniel Brandeis Alexander Roth Martina Röthlisberger Maya Schneebeli Susanne Walitza Silvia Brem Simulating reading acquisition: The link between reading outcome and multimodal brain signatures of letter–speech sound learning in prereaders
description	Abstract During reading acquisition, neural reorganization of the human brain facilitates the integration of letters and speech sounds, which enables successful reading. Neuroimaging and behavioural studies have established that impaired audiovisual integration of letters and speech sounds is a core deficit in individuals with developmental dyslexia. This longitudinal study aimed to identify neural and behavioural markers of audiovisual integration that are related to future reading fluency. We simulated the first step of reading acquisition by performing artificial-letter training with prereading children at risk for dyslexia. Multiple logistic regressions revealed that our training provides new precursors of reading fluency at the beginning of reading acquisition. In addition, an event-related potential around 400 ms and functional magnetic resonance imaging activation patterns in the left planum temporale to audiovisual correspondences improved cross-validated prediction of future poor readers. Finally, an exploratory analysis combining simultaneously acquired electroencephalography and hemodynamic data suggested that modulation of temporoparietal brain regions depended on future reading skills. The multimodal approach demonstrates neural adaptations to audiovisual integration in the developing brain that are related to reading outcome. Despite potential limitations arising from the restricted sample size, our results may have promising implications both for identifying poor-reading children and for monitoring early interventions.
format	article
author	Iliana I. Karipidis Georgette Pleisch Daniel Brandeis Alexander Roth Martina Röthlisberger Maya Schneebeli Susanne Walitza Silvia Brem
author_facet	Iliana I. Karipidis Georgette Pleisch Daniel Brandeis Alexander Roth Martina Röthlisberger Maya Schneebeli Susanne Walitza Silvia Brem
author_sort	Iliana I. Karipidis
title	Simulating reading acquisition: The link between reading outcome and multimodal brain signatures of letter–speech sound learning in prereaders
title_short	Simulating reading acquisition: The link between reading outcome and multimodal brain signatures of letter–speech sound learning in prereaders
title_full	Simulating reading acquisition: The link between reading outcome and multimodal brain signatures of letter–speech sound learning in prereaders
title_fullStr	Simulating reading acquisition: The link between reading outcome and multimodal brain signatures of letter–speech sound learning in prereaders
title_full_unstemmed	Simulating reading acquisition: The link between reading outcome and multimodal brain signatures of letter–speech sound learning in prereaders
title_sort	simulating reading acquisition: the link between reading outcome and multimodal brain signatures of letter–speech sound learning in prereaders
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/b09daeef335e4262bd7a65b2e27853b2
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Simulating reading acquisition: The link between reading outcome and multimodal brain signatures of letter–speech sound learning in prereaders

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